Protein GPI map

Identifiers
glucose-6-phosphate isomerase
HUGO:GPI HGNC:4458 ENTREZ:2821 UNIPROT:P06744

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 RECON2  map

GPI@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

GPI|​hm2@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re248( Regulated Cell Death  map ):
PMID:15637053
in human fibrosarcoma HT1080 cells, phosphorylation of GPI by CK2 decreases its enzymatic activity and (non-phosphorylatable or phospho-mimetic mutants)
in HT1080, knock-down of CK2 promotes GPI activity
in vitro, in HT1080 cells, phosphomimetic GPI mutant forms tetramers
in vitro, CK2 triggers GPI tetramerisation
PMID:11004567
in vitro CK2 mediated phosphorylation of GPI on S185
in HT1080 cells, Ser phosphorylation of GPI

GPI|​S185_pho|​hm4@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re248( Regulated Cell Death  map ):
PMID:15637053
in human fibrosarcoma HT1080 cells, phosphorylation of GPI by CK2 decreases its enzymatic activity and (non-phosphorylatable or phospho-mimetic mutants)
in HT1080, knock-down of CK2 promotes GPI activity
in vitro, in HT1080 cells, phosphomimetic GPI mutant forms tetramers
in vitro, CK2 triggers GPI tetramerisation
PMID:11004567
in vitro CK2 mediated phosphorylation of GPI on S185
in HT1080 cells, Ser phosphorylation of GPI

Modifications:
In compartment: Cytosol
  1. GPI@Cytosol map
  2. GPI|​hm2@Cytosol map
  3. GPI|​S185_pho|​hm4@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rGPI@Nucleus map → map GPI@Cytosol map
    2. GPI|​hm2@Cytosol map → map GPI|​S185_pho|​hm4@Cytosol map
    3. GPI@Cytosol map → map GPI|​hm2@Cytosol map
    As Catalyser:
    1. glucose-6P@Cytosol map → map fructose-6P@Cytosol map