Identifiers
HCLS1 associated protein X-1
HUGO:HAX1 HGNC:16915 ENTREZ:10456 UNIPROT:O00165
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
References
rc_re103( Regulated Cell Death ):
PMID:16857965
identification by Y2H
co-IP
in vitro, HAX1 prevents the processing of CASP9
in rat cardiac myocytes, HAX1 prevents the processing of CASP9 and attenuates apoptosis induced by hypoxia/reperfusion (ectopic expression, RNA interfernce)
interaction takes place within mitochondria (data not shown)
rc_re653:( Regulated Cell Death ) PMID:15371414
+ HAX1@Mitochondrial intermembrane space → Caspase9*:HAX1@Mitochondrial intermembrane space
→ cleaved~HAX1*@Mitochondrial intermembrane space