Identifiers
HUGO:ILK
References
CASCADE:INTEGRIN
PMID:11696562
Integrin-linked kinase (ILK) is a binding partner of the integrin 1 and 3 subunits and is involved in the signal transduction from integrin receptors
The activity is stimulated in a phosphatidylinositol (PI) 3-kinase???dependent manner and likely involves binding of the phosphoinositide phospholipid product of PI 3-kinase, PI 3,4,5-triphosphate, to the PH-like domain of ILK
ILK has been shown recently to directly phosphorylate proteins such as PKB (PKB/Akt) on ser 473.
PMID:15905178
Knock-down of ILK by small, interfering RNA (siRNA) attenuated Akt phosphorylation in response to ligation of beta1 integrin by collagen or activating antibody and enhanced fibroblast apoptosis in response to collagen contraction.
PMID:27111285
ILK???PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast