Identifiers
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
HUGO:ID2, HGNC:5361, ENTREZ:3398, UNIPROT:Q02363, GENECARDS:GC02P008818
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
PMID:11708773
PMID:15252039
ID2 is target of HIF1 upon hypoxic conditions
PMID:15121845
PMID:18832382
Id2 or Id3 can form complexes with TCF3 (E47), and inhibit the process of EMT.
Id2 and Id3 define the epithelial context that allows proper growth and differentiation responses to specific TGFB superfamily factors
PMID:15689496
Id2 (and Id3) must be down-regulated by TGFB pathway in order for EMT to occur.
ID2 is repressed by TGFB1 but induced by BMP7
Under conditions of Id2 knockdown, BMP-7 is capable of inducing significant alpha-smooth Actin level