Gene ID3 map

Identifiers
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
HUGO:ID3, HGNC:5362, ENTREZ:3399, UNIPROT:Q02535, GENECARDS:GC01M023884
HUGO:ID3

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSUPPRESSIVE  map

References
PMID:11708773
PMID:15252039
ID2 is target of HIF1 upon hypoxic conditions
 MACROPHAGE  map
 MDSC  map
CASCADE:LGALS1
CASCADE:IL10
PMID:21191065
regulatory effect of galectin-1 is mediated, in part, through its ability to induce, in an Id3 (inhibitor of DNA binding 3)-dependent manner, the expression of IL-10 in monocytes and MdDCs.
At the same tyme IL10 siglaning also participates in ID3 upregulation via PI3K/AKT pathway
(autocrine loop)

gID3@Nucleus

References
em_emtc_emtc_re1351( EMT Senescence  map ):
PMID:17615296
TGFB induces ETS1 transcriptional expression.
TGFB represses ID2 and ID3 transcriptional expression (PMID:15121845 and PMID:15181457)
ID2 may regulate the function of Ets1 to modulate the transcription of ZEB1 and ZEB2 without alteration of the transcription of Ets1.
Ets1 may act as an inducer of ZEB1 in collaboration with E47 (TCF3)

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gID3@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. gID3@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gID3@Nucleus map → map rID3@Nucleus map
    2. gID3@INNATE_IMMUNE_CELL_Cytosol map → map rID3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: