Gene SIN3A map

Identifiers
SIN3 transcription regulator homolog A (yeast)
SIN3A
HUGO:SIN3A HGNC:19353 ENTREZ:25942 UNIPROT:Q96ST3

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:22796940
Repression of E-cadherin by SNAI1/TWIST1 involves the recruitment of histone remodeling proteins to the promoter, where SNAI1 interacts with histone deacetylase HDAC1 and HDAC2.
PMID:14673164
Snail interacts in vivo with the E-cadherin promoter and recruits HDAC activity.
Interaction between Snail, HDAC1 and HDAC2, and the corepressor Sin3A is dependent on the SNAG domain of Snail, indicating that the Snail transcription factor mediates the repression by recruitment of chromatin-modifying activities, forming a multimolecular complex to repress E-cadherin expression.

gSIN3A@Nucleus

References
em_emtc_emtc_re1299( EMT Senescence  map ):
PMID:17550342
SNAI2 induces SIN3A expression

Modifications:
In compartment: Nucleus
  1. gSIN3A@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gSIN3A@Nucleus map → map rSIN3A@Nucleus map
    As Catalyser: