Gene CXCL1 map

Identifiers
HUGO:CXCL1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map

References
CASCADE:IL1
PMID:23567181
inhibition of NF-??B signaling, driving expression of CXCL1 and CXCL2 in skin CAFs resulted in decreased macrophage infiltration into transplanted skin tumors, and reduced tumor growth, indicating a central role for CAFs in facilitating the trafficking of macrophages into tumors
PMID:20138012
PTGS2, CXCL1, and CXCL2; the proinflammatory cytokines IL-1?? and IL-6, CYR61 and OPN are upregulated in CAFs
probably downstream of IL1B via NFkB

Modifications:
In compartment: Cytosol
  1. gCXCL1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gCXCL1@Cytosol map → map rCXCL1@Cytosol map
    As Catalyser: