RNA SMAD2 map

Identifiers
SMAD family member 2
"MAD, mothers against decapentaplegic homolog 2 (Drosophila)", MADH2, "SMAD, mothers against DPP homolog 2 (Drosophila)"
HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796
HUGO:SMAD2

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
CASCADE:TGFB
CASCADE:IL12
CASCADE:IL18
PMID:16713975
SMAD2, SMAD3 and SMAD4 participate in suppression of TBX21 (T-BET) promoter activity downstream of TGFB.
costimulation of NK cells with IL-12 and IL-18 downregulated SMAD2 transcript.

rSMAD2@Nucleus

References
em_emtc_emtc_re1160( EMT Senescence  map ):
PMID:22753312
direct regulation of SMAD2 by miR-141/200c/30e

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rSMAD2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. rSMAD2@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. MIR30E:​SMAD2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rSMAD2_TGFBR1*@Nucleus map → map rSMAD2@Nucleus map
  2. rSMAD2_TGFB2*@Nucleus map → map rSMAD2@Nucleus map
  3. arMIR30E@Nucleus map + rSMAD2@Nucleus map → map MIR30E:​SMAD2@Cytosol map
  4. gSMAD2@Nucleus map → map rSMAD2@Nucleus map
  5. rSMAD2@Nucleus map → map SMAD2@Cytosol map
  6. gSMAD2@INNATE_IMMUNE_CELL_Cytosol map → map rSMAD2@INNATE_IMMUNE_CELL_Cytosol map
  7. rSMAD2@INNATE_IMMUNE_CELL_Cytosol map → map SMAD2@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: