Identifiers
NAME:AXIN2:GSK3_beta_*
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
PMID:17072303
AXIN2 acts as nucleocytoplasmic chaperon for GSK3B thus increase SNAIL1 stability.
PMID:22745173
Control of nuclear activity of GSK3B is AXIN2-dependent.
Axin2 serves as a negative regulator of nuclear GSK3B activity that allows for the stabilization of nuclear Snail1 levels and activity