Identifiers
radixin
HUGO:RDX, HGNC:9944, ENTREZ:5962, GENECARDS:GC11M110045 , UNIPROT:P35241
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
PMID:9287351
ERM family (ezrin/radixin/moesin)
Direct interaction of the ARHGDI family with ERM family initiates the activation of the Rho small G protein.
PMID:10047517
Regulation of cortical structure by the ERM protein family.
PMID:12045227
Rho-dependent and -independent activation mechanisms of ERM proteins: an essential role for polyphosphoinositides in vivo.
ERM proteins crosslink actin filaments to plasma membranes and are involved in the organization of the cortical cytoskeleton, especially in the formation of microvilli.
ERM proteins are reported to be activated as crosslinkers in a Rho-dependent manner and are stabilized when phosphorylated at their C-terminal threonine residue to create C-terminal threonine- phosphorylated ERM proteins
However, ERM proteins appear to be activated in the absence of Rho activation and remain active without C-terminal phosphorylation.
Phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P2) affected the activation of ERM proteins regardless of cell type.
The Rho-independent activation mechanism of ERM proteins therefore exists.
Both Rho-dependent and -independent activation of ERM proteins require a local elevation of PtdIns(4,5)P2 concentration in vivo.