Complex HDAC1:HDAC2:SIN3A:SNAI1 map
Complex composition:

  1. SNAI1 map
  2. HDAC2 map
  3. HDAC1 map
  4. SIN3A map

HDAC1:​HDAC2:​SIN3A:​SNAI1@Nucleus

Identifiers
NAME:HDAC1:HDAC2:SIN3A:SNAI1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:22796940
Repression of E-cadherin by SNAI1/TWIST1 involves the recruitment of histone remodeling proteins to the promoter, where SNAI1 interacts with histone deacetylase HDAC1 and HDAC2.
PMID:14673164
Snail interacts in vivo with the E-cadherin promoter and recruits HDAC activity.
Interaction between Snail, HDAC1 and HDAC2, and the corepressor Sin3A is dependent on the SNAG domain of Snail, indicating that the Snail transcription factor mediates the repression by recruitment of chromatin-modifying activities, forming a multimolecular complex to repress E-cadherin expression.

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. HDAC1:​HDAC2:​SIN3A:​SNAI1@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. SNAI1@Nucleus map + HDAC1@Nucleus map + HDAC2@Nucleus map + SIN3A@Nucleus map → map HDAC1:​HDAC2:​SIN3A:​SNAI1@Nucleus map
As Catalyser:
  1. gE-Cadherin*@Nucleus map → map rE-Cadherin*@Nucleus map