Protein CD48 map

Identifiers
HUGO:CD48

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map
 Adaptive Immune Response  map  / ACTIVATING_CHECKPOINTS  map

References
PMID:26794910
 NATURAL_KILLER  map
CASCADE:2B4
PMID:10359122, PMID:16081768
CD48 is a counter-receptor for 2B4 receptor, which is widely expressed on hemopoietic cells.
NK cells costimulate each other through 2B4-CD48 interactions.
PMID:15998796
Expression of CD48 was detected on the membrane of some tumor cells,all of which were found to be lysed by a SAP-dependent NK cell cytotoxicity.

Modifications:
In compartment: Cancer_cell
  1. CD48@Cancer_cell map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD48@INNATE_IMMUNE_CELL_Membrane map
In compartment: pSMAC
  1. CD48@pSMAC map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
  2. 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
In compartment: pSMAC
  1. CD2:​CD48@pSMAC map
Participates in reactions:
As Reactant or Product:
  1. CD48@pSMAC map + CD2@pSMAC map → map CD2:​CD48@pSMAC map
  2. Ligands_of_activating_immune checkpoints@Cancer_cell map → map CD48@Cancer_cell map
  3. CD48@INNATE_IMMUNE_CELL_Membrane map + 2B4*@INNATE_IMMUNE_CELL_Membrane map + SH2D1A@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
  4. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map + 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CD244@T_cell map → map CD244@T_cell map
  2. CD2@T_cell map → map CD2@T_cell map
  3. LAT@T_cell map → map LAT@T_cell map
  4. LCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. PLCG2@INNATE_IMMUNE_CELL_Cytosol map → map PLCG2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. PLCG1@INNATE_IMMUNE_CELL_Cytosol map → map PLCG1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  7. CBL@INNATE_IMMUNE_CELL_Cytosol map → map CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  8. 3BP2*@INNATE_IMMUNE_CELL_Membrane map → map 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map
  9. LAT|​pho@INNATE_IMMUNE_CELL_Cytosol map → map LAT@INNATE_IMMUNE_CELL_Cytosol map
  10. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map