Identifiers
ribosomal protein S6 kinase 90kDa polypeptide 4
"ribosomal protein S6 kinase 90kD polypeptide 4"
HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676
ribosomal protein S6 kinase 90kDa polypeptide 5
"ribosomal protein S6 kinase 90kD polypeptide 5"
HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates.
PMID:15187187
References
su_mpk1_mpk1_re95( Survival ):
MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates.
PMID:15187187
References
su_mpk1_mpk1_re95( Survival ):
MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates.
PMID:15187187
su_mpk1_mpk1_re96( Survival ):
MSK1 rather than RSK1 mediates the mitogen-stimulated phoshphorylation of CREB.
su_mpk1_mpk1_re260( Survival ):
Translocation of ERK into the nucleus activates the mitogen activated and stress-activated protein kinase 1 (MSK1) a histone H3 kinase that can relax chromatin thus making it more transcriptionally accessible. This alteration in the chromatin state induces MYC a gene that encodes the C-MYC protein a transcription factor that controls the cell cycle.
PMID:17158541