Identifiers
cyclin D3
HUGO:CCND3, HGNC:1585, ENTREZ:896, GENECARDS:GC06M041949, UNIPROT:P30281
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
References
PMID:21777377
Further studies are required to investigate the mechanism by which Cx31.1 repress cyclin D3 expression
References
em_emtc_emtc_re673( EMT Senescence ):
GJB5 is so-called Connexin 31.1
PMID:21777377
Cx31.1 (GJB5) is predominantly expressed in the testes and the skin epidermis.
Cx31.1 rarely form functional gap junction channels, either with itself or with other Cx isoforms.
Gap junctions play important roles in various physiologic functions such as regulation of cell proliferation, cell differentiation, tissue development and cell apoptosis.
In most cases, Cxs act as tumour suppressors: Gap junctions play an important role as tumour suppressors in maintaining cell differentiation and preventing transformation
Cx31.1 reduced tumour cell proliferation, anchorage-independent growth, migration and invasion.
Moreover, development of tumours in a xenograft model was suppressed by Cx31.1, suggesting that Cx31.1 may act as a tumour suppressor in NSCLC cell lines.
Further studies are required to investigate the mechanism by which Cx31.1 repress cyclin D3 expression