Antisense RNA MIR31 map

Identifiers
HUGO:MIR31
microRNA 31
HUGO:MIR31, HGNC:31630, ENTREZ:407035, GENECARDS:GC09M021507
HUGO:MIR31 HGNC:31630 ENTREZ:407035
MIRN31
HUGO:MIR31 HGNC:31630 ENTREZ:407035 GENECARDS:MIR31 KEGG:407035 ATLASONC:GC_MIR31 WIKI:MIR31

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:23171795
Downregulation of miR-31 and miR-214 and upregulation of miR-155 was confirmed in all CAF and induced CAF samples;
CCL5 is a Target of miR-214 . The CCL5 secreted by CAFs is a key tumor-promoting factor.
PMID:20980827
miR-31 directly targets the homeobox gene SATB2, which is responsible for chromatin remodeling and regulation of gene expression, and was significantly elevated in CAFs. The functional relevance of miR-31 and SATB2 were tested in in vitro models of endometrial cancer. Overexpression of miR-31 significantly impaired the ability of CAFs to stimulate tumor cell migration and invasion, without affecting tumor cell proliferation. Genetic manipulation of SATB2 levels in normal fibroblasts or CAFs showed that, reciprocally to miR-31, SATB2 increased tumor cell migration and invasion, while knock-down of endogenous SATB2 in CAFs reversed this phenotype. Introduction of SATB2 into normal fibroblasts stimulated expression of a number of genes involved in cell invasion, migration and scattering.
PMID:24272429
PMID:23665507
PMID:23377965
PMID:24206455
PMID:23453900
PMID:21145728
PMID:22902544
PMID:23550650

Modifications:
In compartment: Cytosol
  1. arMIR31@Cytosol map
In compartment: Nucleus
  1. arMIR31@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. MIR31:​SATB2@Cytosol map
In compartment: Nucleus
  1. FZD3:​MIR31@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. arMIR31@Cytosol map + rSATB2@Cytosol map → map MIR31:​SATB2@Cytosol map
  2. MIR31:​SATB2@Cytosol map → map degraded
  3. gMIR31@Cytosol map → map arMIR31@Cytosol map
  4. arMIR31@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
  5. gMIR31@Nucleus map → map arMIR31@Nucleus map
  6. gMIR31@Nucleus map → map arMIR31@Nucleus map
  7. rFZD3@Nucleus map + arMIR31@Nucleus map → map FZD3:​MIR31@Nucleus map
  8. FZD3:​MIR31@Nucleus map → map degraded
As Catalyser:
  1. rE2F2@Nucleus map → map E2F2@Cytosol map
  2. rCDKN2A@Nucleus map → map CDKN2A@Cytosol map