1. BCL2
2. p53*

Identifiers
NAME:BCL2:p53*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 

References
PMID:12667443
Fraction of induced p53 translocates to the mitochondria of apoptosing tumor cells. Targeting p53 to mitochondria is sufficient to launch apoptosis.
p53 protein can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BCL2L1 and BCL2 proteins, resulting in cytochrome c release.
PMID:14963330
In other hand, cytosolic localization of endogenous p53 was necessary and sufficient for apoptosis. p53 directly activated the pro-apoptotic BCL2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program.
Binding of BCL2 or BCL2L1 to TP53 therefore antagonizes the activation of BAX via binding to TP53. Like this BCL2 and BCL2L1 also perform their anti-apoptotic effect.
em_emtc_emtc_re433( EMT Senescence  ):
p53 induces apoptosis by target gene regulation and transcription-independent signaling.
A fraction of induced p53 translocates to the mitochondria of apoptosing tumor cells. Targeting p53 to mitochondria is sufficient to launch apoptosis.
Evidence that p53 translocation to the mitochondria occurs in vivo in irradiatedthymocytes was shown.

Identifiers
NAME:BCL2:p53*

References
rc_re1406( Regulated Cell Death  ):
PMID:18845789
unphosphorylated TP53 from coIP experiments with okadaic acid (PKC inhibitor) or ceramide C2 (potent inductor of PP1/2A
PMID:26801188

1. BCL2:​p53*@Mitochondria

1. BCL2:​p53*@Mitochondrial inner membrane

1. p53*@Mitochondria + BCL2@Mitochondria → BCL2:​p53*@Mitochondria
2. BCL2|​unk@Mitochondrial inner membrane + p53*|​S15_unk@Cytosol → BCL2:​p53*@Mitochondrial inner membrane