Protein TSLP map

Identifiers
thymic stromal lymphopoietin
HUGO:TSLP hgnc_id:HGNC:30743 HGNC:30743 ENTREZ:85480 UNIPROT:Q969D9

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
 Cancer Associated Fibroblasts  map  / TREG_MODULATORS  map

References
CASCADE:TNF
CASCADE:IL1
PMID:21339327
TSLP is produced by cancer-associated fibroblasts (CAFs) after activation by tumor-derived TNF and IL-1??
TSLP-containing supernatants from activated CAFs induced in vitro myeloid DCs to up-regulate the TSLP receptor (TSLPR), secrete Th2-attracting chemokines, and acquire TSLP-dependent Th2-polarizing capability in vitro.
PMID:22270071
Probably IL1 and TNF regulate TSLP expression via NFkB

Modifications:
In compartment: Cytosol
  1. TSLP@Cytosol map
In compartment: Treg modulation
  1. TSLP@Treg modulation map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rTSLP@Cytosol map → map TSLP@Cytosol map
    2. TSLP@Cytosol map → map TSLP@Treg modulation map
    As Catalyser: