Protein SMURF2 map

Identifiers
SMAD specific E3 ubiquitin protein ligase 1
HUGO:SMURF1 hgnc_id:HGNC:16807 HGNC:16807 ENTREZ:57154 UNIPROT:Q9HCE7
SMAD specific E3 ubiquitin protein ligase 2
HUGO:SMURF2, HGNC:16809, ENTREZ:64750, GENECARDS:GC17M062540, UNIPROT:Q9HAU4

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map

References
CASCADE:TGFB
PMID:15265520
SMAD7 has been shown to interact with the E3 ubiquitin ligases Smurf 1 and Smurf 2, recruiting them to T??R complexes and inducing the degradation of activated T??RI
PMID:14722617
Overexpression of Smurf1 and Smurf2 further significantly reduced the levels of T??RI protein in normal fibroblasts treated with TGF-??1

Modifications:
In compartment: Cytosol
  1. SMURF2@Cytosol map
In compartment: Nucleus
  1. SMURF2@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. SMURF*@Nucleus map → map SMURF2@Nucleus map
    As Catalyser:
    1. TGFBR1@Cytosol map → map degraded