Complex SLC3A2:SLC7A11
Complex composition:
- SLC3A2
- SLC7A11
SLC3A2:SLC7A11@Cytosol
Identifiers
NAME:SLC3A2:SLC7A11
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death
/ FERROPTOSIS
References
PMID:27048822
SLC3A2:SLC7A11@INNATE_IMMUNE_CELL_Membrane
Identifiers
NAME:SLC3A2:SLC7A11
References
MACROPHAGE
PMID:20414655, PMID:2880923, PMID:3115975
Macrophages import cystine through their x c ??? transporter, reduce it to cysteine and then export the cysteine through their ASC neutral amino acid transporter.
Modifications:
Participates in complexes:
In compartment: Cytosol
- SLC3A2:SLC7A11@Cytosol
In compartment: INNATE_IMMUNE_CELL_Membrane
- SLC3A2:SLC7A11@INNATE_IMMUNE_CELL_Membrane
Participates in reactions:
As Reactant or Product:- SLC3A2@INNATE_IMMUNE_CELL_Cytosol
+ SLC7A11@INNATE_IMMUNE_CELL_Cytosol
→
SLC3A2:SLC7A11@INNATE_IMMUNE_CELL_Membrane
As Catalyser:- Cystine@default
→
Cystine@INNATE_IMMUNE_CELL_Cytosol
- L-cystine@Extracellular space
+ L-glutamate@Cytosol
→
L-cystine@Cytosol
+ L-glutamate@Extracellular space