Protein FKBP1A map

Identifiers
FK506 binding protein 1A
HUGO:FKBP1A hgnc_id:HGNC:3711 HGNC:3711 ENTREZ:2280 UNIPROT:P62942

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
CASCADE:TGFB
PMID:14766396 , PMID:11226255
FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby providing a molecular "gradient reader" for TGF-beta family morphogens.
Unphosphorylated T??RI forms complexes with the FK506-binding protein (FKBP12). Binding of the latter to the GS region of T??RI caps the T??RII phosphorylation sites, thus further stabilizing T??RI in its inactive conformation

Modifications:
In compartment: Cytosol
  1. FKBP1A@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. TGFBR1@Cytosol map + TGFBR2@Cytosol map + TGFB*@default map → map TGFB*:​TGFBR1:​TGFBR2@Cytosol map