Protein DNM2 map

Identifiers
HUGO:DNM2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / LYSOSOME_ENDOSOME  map

References
PMID:15696170
PMID:25234227
Dynamin 2 act on the actin cytoskeleton by:
- Promoting membrane remodeling and endocytosis of cell receptor thanks to NDPKA (NME1) and NDPKB (NME2)
DNM2 induces E-cadherin internalisation
- Promoting cytokinesis and chromosome stability thanks to NDPKA
Loss of NDPK-A is linked to cytokinesis failure and tetraploidy

Modifications:
In compartment: T_cell
  1. DNM2@T_cell map
Participates in complexes:
In compartment: T_cell
  1. DNM2:​VAV1|​pho@T_cell map
Participates in reactions:
As Reactant or Product:
  1. DNM2@T_cell map + VAV1|​pho|​active@T_cell map → map DNM2:​VAV1|​pho@T_cell map
As Catalyser:
  1. Actin cytoskeletal*@T_cell map → map Actin cytoskeletal*|​hm2@T_cell map