Drug Topoisomerase inhibitors* map
Topoisomerase inhibitors*@Nucleus

Identifiers
Compounds that inhibit activity of Topoisomerase family, interferes with replication, transcription and DNA repair
Topoisomerase I inhibitors: irinotecan, topotecan, camptothecin, lamellarin D
Topoisomerase II inhibitors: etoposide (VP-16), teniposide, doxorubicin, daunorubicin, mitoxantrone, amsacrine, ellipticines, aurintricarboxylic acid, HU-331

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / HR  map
 Cell Cycle DNA Repair  map  / C_NHEJ  map
 Cell Cycle DNA Repair  map  / FANCONI  map

References
http://dnatraffic.ibb.waw.pl/classification/dna_damages
PMID:23259582
For HR
PMID:22123462, PMID:20693240
FOR Fanconi
PMID:21414716, PMID:23157317
ce_re513( Cell Cycle DNA Repair  map ):
PMID:22258607, PMID:19267553, PMID:18256616
For C_NHEJ activation by IR
PMID:20691907, PMID:23012265, PMID:21785230
For C_NHEJ activation by UV
PMID:17293412, PMID:15367581
Topoisomerate inhibitors bloch double strand DNA repair by HR, C_NHEJ and Fanconi pathways
For activation by Dbait
PMID:22068457, PMID:22815765, PMID:22042585, PMID:19621083
ce_re515( Cell Cycle DNA Repair  map ):
FOR HR activation by IR
PMID:20723763
For HR activation by UV
PMID:21885354, PMID:22987150, PMID:20206282, PMID:19398948, PMID:1575062
Interstrand crosslinking agents activate HR
PMID:21701511
ce_re520( Cell Cycle DNA Repair  map ):
PMID:17145857
Fanconi is activated by interstrand crosslinking agents
PMID:23444773, PMID:21948210, PMID:21701511

Modifications:
In compartment: Nucleus
  1. Topoisomerase inhibitors*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. gIntact_DNA*@Nucleus map → map gC_NHEJ_DNA_st1*@Nucleus map
      2. gIntact_DNA*@Nucleus map → map gHR_DNA_st1*@Nucleus map
      3. gIntact_DNA*@Nucleus map → map gFanconi_DNA_st1*@Nucleus map