Protein APBB1 map

Identifiers
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
HUGO:APBB1 HGNC:581 ENTREZ:322 UNIPROT:O00213

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
synonym:FE65

APBB1@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map

References
rc_re1494( Regulated Cell Death  map ):
PMID:16818236
upon UVA irradiation (no DSB), phosphorylation of H2AX S139 by JNK
effect of Y142 phosphorylation not assessed
PMID:19234442
interaction between JNK1 and H2AX Y142_pho dependent on FE65 (proposed FE65 scaffolding JNK to Y142_pho)
they propose H2AX Y142 phosphorylation as a switch toward apoptosis.
Even if not fully documented, the information from these 2 papers is merged into this representation where doubly phosphorylated H2AX cooperated with CAD for DNA fragmentation

Modifications:
In compartment: Nucleus
  1. APBB1@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. H2AFX|​Y142_pho@Nucleus map → map H2AFX|​pho|​Y142_pho@Nucleus map