Protein Epherin family* map

Identifiers
ephrin-A1
EPLG1, TNFAIP4
HUGO:EFNA1 HGNC:3221 ENTREZ:1942 UNIPROT:P20827
ephrin-B1
EPLG2
HUGO:EFNB1 HGNC:3226 ENTREZ:1947 UNIPROT:P98172

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:19074825
The eight members of the ephrin family are divided into distinct A and B subclasses, indicating the manner in which they are anchored to the membrane:
either by a glyco- sylphosphatidylinositol (GPI) linkage (ephrinA1-A5) or by a transmembrane domain (ephrinB1-B3).
A unique property of ephrins that is a result of membrane localization is their ability to transduce ??????reverse?????? signals into the cells on which they are expressed in addition to eliciting ??????forward?????? signaling into Eph receptor-expressing cells
Another unique aspect of ephrins that sets them apart from other RTK ligands is that their membrane- bound nature is thought to be required to elicit full Eph receptor activation.

Modifications:
In compartment: Extracellular space
  1. Epherin family*@Extracellular space map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Epherin family*@Extracellular space map → map Epherin-A1*@Extracellular space map
    2. Epherin family*@Extracellular space map → map Ephrin-B1*@Extracellular space map
    As Catalyser: