Complex SMAD3:SMAD4:SNAI1 map
Complex composition:

  1. SMAD4 map
  2. SNAI1 map
  3. SMAD3 map

(SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4:​SNAI1)|​active@Nucleus

Identifiers
NAME:SMAD3:SMAD4:SNAI1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:21041997
Smad3 and Smad4 form a complex with Snail1(SNAI1) that binds to E-box and Smad-binding elements in the promoters of the genes encoding E-Cadherinm Occludinm and the tight junction-associated cell adhesion molecule CAR, consequently repressing their transcription.
em_emtc_emtc_re235( EMT Senescence  map ):
PMID:19597490
SMAD3 and SMAD4 interact and form a complex with SNAIL1

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. (SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4:​SNAI1)|​active@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. SNAI1@Nucleus map + (SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4)|​active@Nucleus map → map (SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4:​SNAI1)|​active@Nucleus map
As Catalyser:
  1. gCAR*@Nucleus map → map rCAR*@Nucleus map
  2. gClaudin3*@Nucleus map → map rClaudin3*@Nucleus map
  3. gE-Cadherin*@Nucleus map → map rE-Cadherin*@Nucleus map
  4. gOccludin*@Nucleus map → map rOccludin*@Nucleus map