Protein SPARC map

Identifiers
secreted protein acidic and cysteine rich
HUGO:SPARC hgnc_id:HGNC:11219 HGNC:11219 ENTREZ:6678 UNIPROT:P09486

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / FIBROBLAST_ACTIVATION_MARKERS  map
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map

References
PMID:17260013
SPARC prevents fibroblast activation in 293 xenografts, suggesting that the anti-cancer effects of SPARC may be due, at least in part, to the formation of tumor stroma that is not supportive of tumor growth.
PMID:17235047
SPARC is a marker of fibroblast activation
patients whose pancreatic cancer stromal fibroblasts expressed SPARC (median survival, 15 months) had a significantly worse prognosis than patients whose tumor stroma did not express SPARC (median survival, 30 months; In contrast, the expression of SPARC in pancreatic cancer cells was not associated with prognosis

Modifications:
In compartment: Cytosol
  1. SPARC@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. SPARC@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
    2. SPARC@Cytosol map → map MARKERS_OF_FIBROBLAST_ACTIVATION@default map
    As Catalyser: