Protein EDN1 map

Identifiers
endothelin 1
HUGO:EDN1 hgnc_id:HGNC:3176 HGNC:3176 ENTREZ:1906 UNIPROT:P05305

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / FIBROBLAST_ACTIVATION_MARKERS  map

References
PMID:21674557
Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts.
This effect is mediated by up-regulation of specific genes related to a myo/contractile phenotype (ACTA2, CNN1,FN (ED-A containing), EDN1, MYL12A, TAGLN2) and inhibition of ACTG2 expression.

Modifications:
In compartment: Cytosol
  1. EDN1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rEDN1@Cytosol map → map EDN1@Cytosol map
    2. EDN1@Cytosol map → map MARKERS_OF_FIBROBLAST_ACTIVATION@default map
    As Catalyser: