Identifiers
HUGO:ARPC3

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / MOTILITY 

References
PMID:11395419
Arp2/3 complex is intrinsically inactive, relying on nucleation promoting factors for activation. WASp/Scar family proteins are prominent cellular nucleation promoting factors. They bring together an actin monomer and Arp2/3 complex in solution or on the side of an existing actin filament to initiate a new filament that grows in the barbed end direction.
 MACROPHAGE 
 NATURAL_KILLER 
CASCADE:CR3
CASCADE:Fc_gamma_RII

1. (ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5)|​active@Cytosol

1. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@INNATE_IMMUNE_CELL_Cytosol
2. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol

1. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@T_cell
2. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​Tyr291_pho@T_cell

1. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@T_cell + WASP*|​Tyr291_pho|​active@T_cell → ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​Tyr291_pho@T_cell
2. (ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5)|​active@Cytosol → (ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5)|​active@Cytosol
3. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@INNATE_IMMUNE_CELL_Cytosol + WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol → ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol

1. Actin cytoskeletal*@T_cell → Actin cytoskeletal*|​hm2@T_cell
2. Actin cytoskeletal*@Cytosol → Actin cytoskeletal*|​hm2|​active@Cytosol
3. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol → Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol