Protein FURIN map

Identifiers
furin (paired basic amino acid cleaving enzyme)
FUR, PACE, "paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)", PCSK3
HUGO:FURIN HGNC:8568 ENTREZ:5045 UNIPROT:P09958

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

FURIN@Extracellular space

References
em_emtc_emtc_re226( EMT Senescence  map ):
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
PMID:21900405
TGFB inhibits proliferation
TGFB overproduction causes fibrosis.
Each TGFB gene encodes a preproprotein sequence consisting of a signal peptide, a propeptide (LAP) and the mature TGFB
After translocation into the endoplamic reticulum, TGFB proprotein monomers form homomdimers liked by disulfide bonds, forming pro-TGFB
In the Golgi, the prodomains undergo glycosylation.
Also in the Golgi, FURIN hydolyzes the leavage site from LAP, creating TGFB and LAP-derived homodimers
The 2 homodimers remain noncovalently associated and are secreted.
The LAP-derived homodimer prevents TGFB from binding TGFB receptors.

Modifications:
In compartment: Extracellular space
  1. FURIN@Extracellular space map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map → map Latency-associated protein*|​hm2@Extracellular space map + TGFB1|​hm2|​active@Extracellular space map