Identifiers
HUGO:ITGB2
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / SMAC
Innate Immunity / RECRUITMENT_OF_IMMUNE_CELLS
Innate Immunity / INTEGRINS
Innate Immunity / DANGER_SIGNAL_PATHWAYS
References
PMID:2150484
CASCADE:CR4
CASCADE:CR3
CASCADE:LFA1
CASCADE:IFNG
NATURAL_KILLER
MACROPHAGE
PMID:24343663, PMID:9712030, PMID:10591186
The phosphorylation of Ser329
by PKC was later found to be critical for the association between
DNAM-1 and CD18(LFA-1) in NK cells.17 This association is required
for DNAM-1 signalling.
PMID:19965656
Coengagement of DNAM-1
and CD18 (LFA-)1 by a Drosophila cell line transfected to express CD155 and
intercellular adhesion molecule 1 triggered the IFN-g production by
NK cells, while these ligands alone had no effects, reinforcing the
functional link between DNAM-1 and LFA-1 in driving NK cell
activation.
PMID:19454690
NKG2D ligation leads to increased adhesion and recruitment of beta1 and beta2 integrins to the cytotoxic synapse.
LFA-1 is required for NKG2D-mediated conjugate formation and cytotoxicity.