Identifiers
HUGO:STAT1
signal transducer and activator of transcription 1
HUGO:STAT1 hgnc_id:HGNC:11362 HGNC:11362 ENTREZ:6772 UNIPROT:P42224
signal transducer and activator of transcription 1, 91kDa
HUGO:STAT1 HGNC:11362 ENTREZ:6772 UNIPROT:P42224
"signal transducer and activator of transcription 1 91kD"
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / INHIBITING_CHECKPOINTS
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / INFLAMMATORY_SIGNALING_PATHWAYS
Cancer Associated Fibroblasts / CAF_INHIBITION_ANTITUMOR
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
EMT Senescence / SENESCENCE
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
PMID:21263073 PMID:12796776
_INHIBITION_ANTITUMOR
CASCADE:IFNG
PMID:17559085, PMID:11134049
IFN-?? induced a direct interaction between activated STAT1?? and p300 in normal skin fibroblasts (Ghosh et al., 2001). Furthermore, ectopic expression of p300 overcame the inhibition by IFN-?? and rescued stimulation by TGF-??, suggesting that in response to IFN-??, activated STAT1?? and/or downstream factor(s) sequestered p300, preventing its recruitment to the transcriptional machinery and thereby inhibiting collagen gene transcription (Ghosh et al., 2001). Similarly, IFN-?? suppression of COL1A2 promoter activation by YB-1 also appears to involve p300 sequestration (Higashi et al., 2003).
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
PMID:19833085
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.
PMID:17689680
STAT1 acetilation inhibits its activity in macrophages.
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:14607900
FNG inhibits IL10 signalind via STAT1.
STAT1 overexpression prevents STAT3 homodimerization.
PMID:12193701, PMID:11830590
CD40 expression is upregulated by STAT1 downstream of INFG
and NF-kB downstream of TNF.
PMID:12193701
INFG upregulates TNFR1 and PIPK1 expression, probably via JAK/STAT1 pathway
because this expression is inhibited in presense of SOCS1.
PMID:15814715, PMID:18272812, PMID:17016554
STAT1 is involeved in immunosupresive activity of M2 macrophages and MDSC, probably downstream of IFNG.
PMID:21930765, PMID:8683106, PMID:12967644
IFNA and IFNB act via STAT1 pathway in DC and NK cells
PMID:25960930
Reduced IFN??-induced STAT-1 phosphorylation in Ser727 and CXCL10 secretion in NK cells derived from PKC-?????/??? mice
??11207245
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c,
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II??