Identifiers
HUGO:SRC
SRC proto-oncogene, non-receptor tyrosine kinase
HUGO:SRC hgnc_id:HGNC:11283 HGNC:11283 ENTREZ:6714 UNIPROT:P12931
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog"
HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931
HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 GENECARDS:SRC REACTOME:402877 KEGG:6714 ATLASONC:SRCID448ch20q11 WIKI:SRC
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / ACTIVATING_CHECKPOINTS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / WNT_CANONICAL
References
PMID:26552706
CASCADE:INTEGRIN
CASCADE:CAV
PMID:11476890
Src kinases participate in PTK2 (FAK) phosphorylation downstream of integrin signaling
Src???/??? fibroblasts are slightly defective and fibroblasts deficient for the src, fyn and yes genes exhibit a dramatic defect in the cell adhesion-dependent tyrosine phosphorylation of FAK.
hese observations suggest that cell adhesion-dependent tyrosine phosphorylation of FAK occurs in two phases. The first, autophosphorylation phase, occurs in the absence of Src and results in the tyrosine phosphorylation of FAK residue 397. The second phase occurs following recruitment of Src into complex with FAK and results in phosphorylation of FAK at other tyrosine residues leading to the full activation of FAK and transmission of downstream signals.
PMID:16919435
Integrin-stimulated FAK phosphorylation at Y397 creates a high-affinity binding site for the Src-homology 2 (SH2) domain of SFKs. The binding of Src to FAK can lead to the conformational activation of SFKs and the formation of a transient FAK???Src signaling complex in fibroblasts and epithelial cells
PMID:25572304
FAK undergoes autophosphorylation that leads to its association with Src, resulting in activation of both kinases.
PMID:27216177
FAP as a persistent activator of fibroblastic STAT3 through a uPAR-dependent FAK-Src-JAK2 signaling pathway.
PMID:17517963
Src is involved in activation of Rac (Servitja et al., 2003; Kawakatsu et al., 2005) and Cdc42 (Miyamoto et al., 2003; Tu et al., 2003; Fukuyama et al., 2005) and can inhibit Rho through activation of p190RhoGAP
caveolin-1 stimulates normal Rho GTP loading through inactivation of the Src???p190RhoGAP pathway.
Many activated RTKs induce the Src-dependent activation of PLCG
PMID:17496910