Protein DIAPH1 map

Identifiers
HUGO:DIAPH1
diaphanous homolog 1 (Drosophila)
HUGO:DIAPH1, HGNC:2876, ENTREZ:1729, GENECARDS:GC05M140875, UNIPROT:O60610

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:17306570
PMID:15866170
DRFs (DIAPH1,2,3) are autoinhibited through intramolecular binding of a Diaphanous autoinhibitory domain to a conserved N-terminal regulatory element.
Autoinhibition is relieved through binding of the GTPase RhoA to the N-terminal element.
PMID:16292343
DRFs are regulated by a RhoGTPase-binding domain situated in the N-terminal region and a C-terminal Diaphanous-autoregulatory domain, whose interaction stabilises an autoinhibited inactive conformation.
Binding of active Rho releases DAD and activates the catalytic activity of mDia
PMID:17575049
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.

Modifications:
In compartment: T_cell
  1. DIAPH1@T_cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell map → map Centrosome polarization@T_cell map