References
PMID:12778124
In the inactive form, the pleckstrin homology (PH) domain and the Rho-binding domain (RBD) of ROCK bind to the amino-terminal region of the protein, which forms an autoinhibitory loop.
Activated, GTP-bound Rho binds to the RBD of ROCK, which results in an open conformation of the kinase and frees the catalytic activity.