Catalysis

1. p57KIP2*@Nucleus

References
PMID:17464323
Translocation of p57Kip2 to mitochondria occurs within 20 min after staurosporine (apoptotic agent) application.
In fact, p57Kip2 primarily promotes the intrinsic apoptotic pathways, favoring Bax activation and loss of mitochondrial transmembrane potential, consequent release of cytochrome-c into cytosol, caspase-9 and caspase-3 activation.
In accordance, Bcl2 overexpression is able to inhibit p57Kip2 cell death promoting effect.
Thus, in addition to its established function in control of proliferation, these results reveal a mechanism whereby p57Kip2 influences the mitochondrial apoptotic cell death pathway in cancer cells.