References
PMID:21081489
Ets-1 is a key transcription factor that is known to support angiogenesis.
Certain pro-angiogenic stimulus induce Ets-1 expression, such as:
PMID:9157999
VEGF increased the level of ETS1 mRNA in human umbifical vein endothelial cells and lung microvascular endothelial cells over 5-fold.
Protein levels were shown to increase concordantly.
PMID:15111329
VEGF is a predominant angiogenic factor that mediates ocular neovascularization.
VEGF is increased by hypoxia, which is one of the primary stimuli for ocular neovascularization.
VEGF induces Ets-1 expression in bovine retinal endothelial cells and its expression is PKC/ERK pathway-dependent.
Ets-1 up-regulation is involved in the development of retinal neovascularization, and inhibition of Ets-1 may be beneficial in the treatment of ischemic ocular diseases
PMID:17872466
Angiotensin II is a potent mediator of vascular inflammation through the generation of reactive oxygen species (ROS).
Ang II???induced ROS production and medial hypertrophy in the thoracic aorta were markedly diminished as a result of blocking Ets-1.
Ets-1 functions as a critical downstream transcriptional mediator of Ang II ROS generation by regulating the expression of NAD(P)H oxidase subunits such as p47phox
PMID:18337545
Angiotensin II increases the expression of the transcription factor ETS-1 in mesangial cells
Mesangial cells are specialized cells around blood vessels in the kidneys, at the mesangium
PMID:16682805
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.