→ ETS1@Nucleus References
PMID:21317430
Snail1 induces the nuclear translocation of Ets1, another factor required for Zeb1 expression.
Both Twist and Ets1 bind to the ZEB1 promoter although to different elements: whereas Ets1 interacts with the proximal promoter, Twist does it with a 700-bp sequence upstream of the transcription start site.
Snail1 controls Zeb1 expression at multiple levels and acts cooperatively with Twist in the ZEB1 gene transcription induction.