References
PMID:14657501
SMURF1, but not SMURF2, decreases RHOA level, and this effect is proteasome dependent.
PMID:16472676
Smurf1 could specifically target RhoA but not Cdc42 or Rac1 for degradation.
Smurf1 interacts with the dominant inactive form of RhoA, RhoA N19, which binds constitutively to GEFs in vivo.
Smurf1 also interacts directly with either nucleotide???free or GDP???bound RhoA in vitro;
However, loading with GTPgS inhibits the interaction