Reaction transport em_emtc_emtc_re233 map

em_emtc_emtc_s562 → (SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4)|​active@Nucleus map

No reaction regulators

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:11792802
PMID:8893010
All mammalian R-Smads and Smad4 reside in the cytoplasm
Phosphorylated R-Smads quickly form complexes with Smad4 and possibly prior to nuclear translocation
PMID:9389648
Nuclear translocation of R-Smads is independent of Smad4
Whereas translocation of Smad4 after TGFB siglaing seems to require the presence of an activated R-Smad