Reaction state_transition em_emtc_emtc_re229 map

SMAD3|​S423_pho|​S425_pho@Cytosol map → SMAD3|​S423_pho|​S425_pho|​hm2|​active@Cytosol map

No reaction regulators

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:11792802
Following phosphorylation of R-Smads by TGFBR1, Smad oligomerization is thought to occur.
PMID:9670020
Smad2 and Smad3 form homo-oligomers upon phosphorylation by the constitutively active TGFBR1
This oligomerization does not require Smad4.