Identifiers
laminin subunit gamma 1
HUGO:LAMC1 hgnc_id:HGNC:6492 HGNC:6492 ENTREZ:3915 UNIPROT:P11047
laminin subunit gamma 2
HUGO:LAMC2 hgnc_id:HGNC:6493 HGNC:6493 ENTREZ:3918 UNIPROT:Q13753
laminin subunit gamma 3
HUGO:LAMC3 hgnc_id:HGNC:6494 HGNC:6494 ENTREZ:10319 UNIPROT:Q9Y6N6
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MATRIX_REGULATION
References
CASCADE:INTEGRIN
PMID:26519775
a3b1 integrin is a Laminin receptor
PMID:16572188
Fibroblasts synthesize many of the constituents of the fibrillar ECM such as type I (genes COL1A1, COL1A2), type III (COL3A1) and type V collagen (COL5A1, COL5A2, COL5A3), and fibronectin.
They also contribute to the formation of basement membranes by secreting type IV collagen (COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6) and laminin.