Protein ZFYVE9 map

Identifiers
zinc finger FYVE-type containing 9
HUGO:ZFYVE9 hgnc_id:HGNC:6775 HGNC:6775 ENTREZ:9372 UNIPROT:O95405

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
CASCADE:TGFB
PMID:9865696
ZFYVE9 (SARA, Smad anchor for receptor activation), is a FYVE domain protein that interacts directly with Smad2 and Smad3. SARA functions to recruit Smad2 to the TGFbeta receptor
PMID:19620243
BUT!!!
the transition of epithelial cells to a mesenchymal/fibroblastic phenotype might include a reduction in the expression of SARA.
TGF-??1 treatment for 3 and 5 days resulted in a reduction in SARA corresponding to the timing of an increase in TGF-??1-induced smooth muscle ??-actin (??SMA) expression.

Modifications:
In compartment: Cytosol
  1. ZFYVE9@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. SMAD2@Cytosol map → map SMAD2|​pho@Cytosol map