→ GSK3_beta_*|pho@Cytoplasm References
Glycogen synthase kinase 3 (GSK3) is a target of Akt. This protein kinase is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation. Phosphorylation of GSK3 (both alpha and beta isoforms) by Akt turns off the catalytic activity of this enzyme resulting in the activation of pathways that are normally repressed by GSK3.
PMID:12040186