+ GSK3_beta_*@Cytoplasm + RSK*|pho@Cytoplasm → ERK*|pho|pho:GSK3_beta_*|pho:RSK*|pho@Cytoplasm References
ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex.
PMID:16039586