PPARG
type: DnaRegionReference
xref: HUGO c gn3 PPARG

MEL_18
type: ProteinReference
xref: HUGO c p32 PCGF2

BAF250
type: ProteinReference
xref: HUGO c p53 ARID1A

HUGO c gn30 MXD3
type: RelationshipXref
id: MXD3
db: HGNC

HUGO c gn169 SSR4
type: RelationshipXref
id: SSR4
db: HGNC

BRCA1
type: DnaRegionReference
xref: HUGO d gn61 BRCA1

Pubmed_12527885
type: PublicationXref
id: 12527885
db: pubmed

module_CYCLINB
type: Pathway
pathway component: c0 c re239
pathway component: c0 c re238
pathway component: c0 c re237
pathway component: c0 c re236
pathway component: c re330
pathway component: c0 c re233
pathway component: c re232
pathway component: c re233
pathway component: c re230
pathway component: c re236
pathway component: c re237
pathway component: c re234
pathway component: c re235
pathway component: c1 c re258
pathway component: c0 c re232
pathway component: c re238
pathway component: c re195
pathway component: c re239
pathway component: c re208
pathway component: c0 c re330
pathway component: c re241
pathway component: c0 c re241
pathway component: c1 c re195
pathway component: c0 c re258
pathway component: c0 c re219
pathway component: c re217
pathway component: c re216
pathway component: c re219
pathway component: c re218
pathway component: c0 c re195
pathway component: c re212
pathway component: c re260
pathway component: c0 c re217
pathway component: c0 c re218
pathway component: c0 c re216
pathway component: c re258
pathway component: c0 c re158
pathway component: c re320
pathway component: c re229
pathway component: c re228
pathway component: c re227
pathway component: c re158
pathway component: c re322
pathway component: c re226
pathway component: c re225
pathway component: c0 c re224
pathway component: c re224
pathway component: c0 c re225
pathway component: c0 c re226
pathway component: c0 c re227
pathway component: c re221
pathway component: c re220
pathway component: c0 c re260
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

KNTC2
type: DnaRegionReference
xref: HUGO c gn121 NDC80

module_CYCLINA
type: Pathway
pathway component: c0 c re257
pathway component: c re310
pathway component: c re1273
pathway component: c re1274
pathway component: c re86
pathway component: c re307
pathway component: c re1272
pathway component: c0 c re86
pathway component: c re257
pathway component: c0 c re1272
pathway component: c0 c re310
pathway component: c re171
pathway component: c1 c re257
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

HUGO c gn182 TYMS
type: RelationshipXref
id: TYMS
db: HGNC

module_CYCLIND
type: Pathway
pathway component: c re165
pathway component: c re166
pathway component: c re167
pathway component: c re186
pathway component: c re168
pathway component: c re187
pathway component: c re188
pathway component: c re189
pathway component: c0 c re155
pathway component: c re16
pathway component: c re194
pathway component: c re193
pathway component: c re190
pathway component: c re192
pathway component: c re191
pathway component: c re155
pathway component: c0 c re248
pathway component: c0 c re247
pathway component: c0 c re165
pathway component: c0 c re188
pathway component: c0 c re186
pathway component: c re242
pathway component: c re243
pathway component: c re244
pathway component: c re247
pathway component: c re248
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

module_CYCLINC
type: Pathway
pathway component: c re308
pathway component: c0 c re121
pathway component: c re121
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

RPA2
type: DnaRegionReference
xref: HUGO c gn48 RPA2

module_CYCLINE
type: Pathway
pathway component: c re1275
pathway component: c0 c re248
pathway component: c re306
pathway component: c2 c re289
pathway component: c re169
pathway component: c re323
pathway component: c1 c re289
pathway component: c4 c re289
pathway component: c re329
pathway component: c re147
pathway component: c re327
pathway component: c0 c re147
pathway component: c re251
pathway component: c re250
pathway component: c0 c re169
pathway component: c3 c re289
pathway component: c re252
pathway component: c0 c re323
pathway component: c re248
pathway component: c re170
pathway component: c0 c re329
pathway component: c re289
pathway component: c0 c re251
pathway component: c0 c re289
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

BTRC
type: DnaRegionReference
xref: HUGO c gn118 BTRC

ZNF451
type: DnaRegionReference
xref: HUGO c gn185 ZNF451

WDR36
type: DnaRegionReference
xref: HUGO c gn186 WDR36

HUGO a gn86 SIVA1
type: RelationshipXref
id: SIVA1
db: HGNC

HUGO d gn79 CDC25A
type: RelationshipXref
id: CDC25A
db: HGNC

module_CYCLINH
type: Pathway
pathway component: c re310
pathway component: c re216
pathway component: c re175
pathway component: c re147
pathway component: c0 c re147
pathway component: c re148
pathway component: c0 c re175
pathway component: c0 c re174
pathway component: c0 c re216
pathway component: c re245
pathway component: c0 c re310
pathway component: c re170
pathway component: c re174
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

MCAM
type: DnaRegionReference
xref: HUGO c gn27 MCAM

Pubmed_8832394
type: PublicationXref
id: 8832394
db: pubmed

CSDA
type: DnaRegionReference
xref: HUGO c gn42 CSDA

Pubmed_15133492
type: PublicationXref
id: 15133492
db: pubmed

Pubmed_16580749
type: PublicationXref
id: 16580749
db: pubmed

Pubmed_10998368
type: PublicationXref
id: 10998368
db: pubmed

module_P21CIP
type: Pathway
pathway component: c2 c re289
pathway component: c0 c re298
pathway component: c1 c re289
pathway component: c4 c re289
pathway component: c re262
pathway component: c1 c re92
pathway component: c0 c re178
pathway component: c0 c re179
pathway component: c3 c re289
pathway component: c0 c re1272
pathway component: c2 c re92
pathway component: c0 c re92
pathway component: c re298
pathway component: c2 c re298
pathway component: c re179
pathway component: c1 c re298
pathway component: c re325
pathway component: c re1272
pathway component: c re178
pathway component: c re324
pathway component: c re328
pathway component: c1 c re179
pathway component: c re327
pathway component: c1 c re178
pathway component: c re326
pathway component: c re92
pathway component: c re605
pathway component: c0 c re604
pathway component: c3 c re92
pathway component: c re604
pathway component: c3 c re298
pathway component: c re289
pathway component: c0 c re289
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

CDK1
type: DnaRegionReference
xref: HUGO c gn15 CDK1

Pubmed_8380224
type: PublicationXref
id: 8380224
db: pubmed

HUGO c gn180 TUBA1A
type: RelationshipXref
id: TUBA1A
db: HGNC

PCNA
type: DnaRegionReference
xref: HUGO c gn11 PCNA

HUGO c gn95 POLA2
type: RelationshipXref
id: POLA2
db: HGNC

HUGO c gn95 POLA1
type: RelationshipXref
id: POLA1
db: HGNC

HUGO c gn190 CDCA4
type: RelationshipXref
id: CDCA4
db: HGNC

HUGO c gn63 RBBP4
type: RelationshipXref
id: RBBP4
db: HGNC

Pubmed_15829956
type: PublicationXref
id: 15829956
db: pubmed

SLC25A14
type: DnaRegionReference
xref: HUGO c gn164 SLC25A14

Pubmed_16135794
type: PublicationXref
id: 16135794
db: pubmed

HUGO c gn47 RBM25
type: RelationshipXref
id: RBM25
db: HGNC

PRKDC
type: DnaRegionReference
xref: HUGO c gn94 PRKDC

CBP
type: ProteinReference
xref: HUGO d pr313 CREBBP

Pubmed_9268380
type: PublicationXref
id: 9268380
db: pubmed

Pubmed_1384126
type: PublicationXref
id: 1384126
db: pubmed

SOAT2
type: DnaRegionReference
xref: HUGO c gn166 SOAT2

Pubmed_1510543
type: PublicationXref
id: 1510543
db: pubmed

DUSP2
type: DnaRegionReference
xref: HUGO c gn159 DUSP2

HUGO c gn87 EXOSC8
type: RelationshipXref
id: EXOSC8
db: HGNC

CyclinA2
type: DnaRegionReference
xref: HUGO c gn80 CCNA2

HUGO a gn63 TP53
type: RelationshipXref
id: TP53
db: HGNC

HUGO d gn81 MAD2L1
type: RelationshipXref
id: MAD2L1
db: HGNC

c4 c re289
type: Catalysis
controlled: c re289
control type: ACTIVATION
controller: CDK4_CyclinD__p21CIP1
comment: CDTYPE:CATALYSIS

HDAC1
type: ProteinReference
xref: HUGO e pr165 HDAC1

Pubmed_16325355
type: PublicationXref
id: 16325355
db: pubmed

SNRPE
type: DnaRegionReference
xref: HUGO c gn161 SNRPE

HUGO c gn141 TP73
type: RelationshipXref
id: TP73
db: HGNC

E2F1_alone
type: ProteinReference
xref: HUGO c pr138 E2F1

HUGO c gn89 CDT1
type: RelationshipXref
id: CDT1
db: HGNC

HUGO c gn55 CYC1
type: RelationshipXref
id: CYC1
db: HGNC

Pubmed_12851486
type: PublicationXref
id: 12851486
db: pubmed

HUGO e pr404 AKT1
type: RelationshipXref
id: AKT1
db: HGNC

Pubmed_16741925
type: PublicationXref
id: 16741925
db: pubmed

RBBP8
type: DnaRegionReference
xref: HUGO c gn64 RBBP8

Pubmed_11937641
type: PublicationXref
id: 11937641
db: pubmed

CHEK2
type: ProteinReference
xref: HUGO d pr126 CHEK2

MNAT1
type: Protein
entity reference: MNAT1

Pubmed_8119945
type: PublicationXref
id: 8119945
db: pubmed

Pubmed_12150994
type: PublicationXref
id: 12150994
db: pubmed

Pubmed_9736735
type: PublicationXref
id: 9736735
db: pubmed

Pubmed_11034215
type: PublicationXref
id: 11034215
db: pubmed

WEE1
type: Protein
entity reference: WEE1

HUGO a gn7 PMAIP1
type: RelationshipXref
id: PMAIP1
db: HGNC

c2 c re298
type: Catalysis
controlled: c re298
control type: ACTIVATION
controller: CDK4_CyclinD__p21CIP1
comment: CDTYPE:CATALYSIS

Pubmed_10753885
type: PublicationXref
id: 10753885
db: pubmed

Pubmed_12838312
type: PublicationXref
id: 12838312
db: pubmed

00696
type: UnificationXref
id: MOD:00696
db: MOD

FBXO5
type: DnaRegionReference
xref: HUGO c gn110 FBXO5

Pubmed_15782160
type: PublicationXref
id: 15782160
db: pubmed

CDC25C
type: Protein
entity reference: CDC25C
feature: c s800 c rs2 phosphorylated

CyclinH
type: Protein
entity reference: CyclinH

CDK7
type: Protein
entity reference: CDK7

BCL2L11
type: DnaRegionReference
xref: HUGO a gn14 BCL2L11

c2 c re289
type: Catalysis
controlled: c re289
control type: ACTIVATION
controller: CDK4_CyclinD__p27KIP1
comment: CDTYPE:CATALYSIS

Pubmed_10567569
type: PublicationXref
id: 10567569
db: pubmed

HUGO c gn125 E2F6
type: RelationshipXref
id: E2F6
db: HGNC

Pubmed_15769944
type: PublicationXref
id: 15769944
db: pubmed

MCM6
type: DnaRegionReference
xref: HUGO c gn51 MCM6

HUGO a gn148 HRK
type: RelationshipXref
id: HRK
db: HGNC

Pubmed_16179649
type: PublicationXref
id: 16179649
db: pubmed

Pubmed_8348613
type: PublicationXref
id: 8348613
db: pubmed

CSTF1
type: DnaRegionReference
xref: HUGO c gn113 CSTF1

HUGO c gn50 RPL32
type: RelationshipXref
id: RPL32
db: HGNC

AXIN2
type: DnaRegionReference
xref: HUGO e gn144 AXIN2

p14ARF
type: ProteinReference
xref: HUGO a pr446 CDKN2A

MTHFD1
type: DnaRegionReference
xref: HUGO c gn99 MTHFD1

Pubmed_15210709
type: PublicationXref
id: 15210709
db: pubmed

Pubmed_14990995
type: PublicationXref
id: 14990995
db: pubmed

MELK
type: DnaRegionReference
xref: HUGO c gn58 MELK

Pubmed_11598127
type: PublicationXref
id: 11598127
db: pubmed

HUGO c gn152 MYCN
type: RelationshipXref
id: MYCN
db: HGNC

Pubmed_12444919
type: PublicationXref
id: 12444919
db: pubmed

Pubmed_12717421
type: PublicationXref
id: 12717421
db: pubmed

RBM25
type: DnaRegionReference
xref: HUGO c gn47 RBM25

Pubmed_15361834
type: PublicationXref
id: 15361834
db: pubmed

NBS1
type: Protein
entity reference: NBS1
feature: c s425 c rs1 phosphorylated

Pubmed_11090622
type: PublicationXref
id: 11090622
db: pubmed

HUGO c p69 SERTAD1
type: RelationshipXref
id: SERTAD1
db: HGNC

p14ARF__at_Nucleus
type: Protein
entity reference: p14ARF

Pubmed_16732330
type: PublicationXref
id: 16732330
db: pubmed

p16INK4A
type: Protein
entity reference: p16INK4A

Pubmed_12909625
type: PublicationXref
id: 12909625
db: pubmed

SERTAD1
type: Protein
entity reference: SERTAD1

TP53INP1
type: DnaRegionReference
xref: HUGO c gn173 TP53IN91

map_cellcycle
type: Pathway
pathway component: c0 c re276
pathway component: c re283
pathway component: c re284
pathway component: c re281
pathway component: c0 c re175
pathway component: c0 c re174
pathway component: c0 c re178
pathway component: c0 c re179
pathway component: c re276
pathway component: c re275
pathway component: c re278
pathway component: c re290
pathway component: c re291
pathway component: c re292
pathway component: c1 c re64
pathway component: c0 c re188
pathway component: c0 c re186
pathway component: c re286
pathway component: c re285
pathway component: c re288
pathway component: c re287
pathway component: c re289
pathway component: c0 c re289
pathway component: c0 c re292
pathway component: c1 c re621
pathway component: c1 c re622
pathway component: c0 c re298
pathway component: c0 c re155
pathway component: c0 c re157
pathway component: c0 c re158
pathway component: c0 c re159
pathway component: c re298
pathway component: c re297
pathway component: c0 c re165
pathway component: c re92
pathway component: c re95
pathway component: c re94
pathway component: c re97
pathway component: c0 c re169
pathway component: c re96
pathway component: c re99
pathway component: c2 c re64
pathway component: c re98
pathway component: c re91
pathway component: c re232
pathway component: c re233
pathway component: c re230
pathway component: c re100
pathway component: c re236
pathway component: c re237
pathway component: c0 c re1272
pathway component: c re234
pathway component: c re235
pathway component: c1 c re258
pathway component: c re238
pathway component: c re239
pathway component: c1 c re257
pathway component: c0 c re330
pathway component: c re251
pathway component: c re250
pathway component: c re241
pathway component: c re242
pathway component: c re243
pathway component: c re244
pathway component: c3 c re92
pathway component: c re245
pathway component: c re247
pathway component: c re248
pathway component: c1 c re265
pathway component: c0 c re195
pathway component: c4 c re289
pathway component: c re262
pathway component: c re261
pathway component: c1 c re132
pathway component: c re260
pathway component: c1 c re92
pathway component: c re258
pathway component: c re257
pathway component: c re254

HUGO c gn113 CSTF1
type: RelationshipXref
id: CSTF1
db: HGNC

GSK3_beta
type: Protein
entity reference: GSK3_beta
feature: c s417 c rs1 phosphorylated

H19
type: DnaRegionReference
xref: HUGO c gn151 H19

AKT1
type: Protein
entity reference: AKT1

GSK3_beta
type: Protein
entity reference: GSK3_beta

Pubmed_15580623
type: PublicationXref
id: 15580623
db: pubmed

MDM2
type: Protein
entity reference: MDM2
feature: c s424 c rs1 phosphorylated

ACTN4
type: DnaRegionReference
xref: HUGO c gn34 ACTN4

MDM2
type: Protein
entity reference: MDM2

HUGO c gn146 ECE1
type: RelationshipXref
id: ECE1
db: HGNC

MCM7
type: DnaRegion
entity reference: MCM7

Pubmed_11331603
type: PublicationXref
id: 11331603
db: pubmed

ATM
type: DnaRegion
entity reference: ATM

RBL1
type: DnaRegion
entity reference: RBL1

E2F2_alone
type: Protein
entity reference: E2F2_alone

HUGO e gn80 CDKN1A
type: RelationshipXref
id: CDKN1A
db: HGNC

HUGO c pr140 PPP1R2
type: RelationshipXref
id: PPP1R2
db: HGNC

E2F1_alone
type: Protein
entity reference: E2F1_alone

E2F_Family
type: PhysicalEntity
comment: This is a CellDesigner UNKNOWN entity.

E2F3_alone
type: Protein
entity reference: E2F3_alone

HUGO c p82 ANAPC2
type: RelationshipXref
id: ANAPC2
db: HGNC

E2F7
type: Protein
entity reference: E2F7

PMAIP1
type: DnaRegionReference
xref: HUGO a gn7 PMAIP1

SNRPE
type: DnaRegion
entity reference: SNRPE

HUGO c p82 ANAPC1
type: RelationshipXref
id: ANAPC1
db: HGNC

p53
type: DnaRegion
entity reference: p53

HUGO c p82 ANAPC7
type: RelationshipXref
id: ANAPC7
db: HGNC

HUGO c gn178 UHRF1
type: RelationshipXref
id: UHRF1
db: HGNC

HUGO c p82 ANAPC4
type: RelationshipXref
id: ANAPC4
db: HGNC

HUGO c p82 ANAPC5
type: RelationshipXref
id: ANAPC5
db: HGNC

HUGO c gn26 LGALS1
type: RelationshipXref
id: LGALS1
db: HGNC

p21CIP1
type: DnaRegionReference
xref: HUGO e gn80 CDKN1A

p53
type: Protein
entity reference: p53

CHEK1
type: ProteinReference
xref: HUGO d pr93 CHEK1

CHEK2
type: Protein
entity reference: CHEK2
feature: c s377 c rs1 phosphorylated

ATR
type: Protein
entity reference: ATR

p68
type: DnaRegion
entity reference: p68

RRM1
type: DnaRegion
entity reference: RRM1

HUGO c gn164 SLC25A14
type: RelationshipXref
id: SLC25A14
db: HGNC

HUGO c gn40 CES1
type: RelationshipXref
id: CES1
db: HGNC

RRM2
type: DnaRegion
entity reference: RRM2

RING1
type: ProteinReference
xref: HUGO c p31 RING1

HUGO c gn40 CES2
type: RelationshipXref
id: CES2
db: HGNC

PBK
type: DnaRegion
entity reference: PBK

CLSPN
type: DnaRegion
entity reference: CLSPN

RPL32
type: DnaRegion
entity reference: RPL32

HUGO c gn40 CES3
type: RelationshipXref
id: CES3
db: HGNC

HUGO c pr83 GTF2H2B
type: RelationshipXref
id: GTF2H2B
db: HGNC

HUGO c pr83 GTF2H2C
type: RelationshipXref
id: GTF2H2C
db: HGNC

HUGO c pr83 GTF2H2D
type: RelationshipXref
id: GTF2H2D
db: HGNC

Pubmed_9190208
type: PublicationXref
id: 9190208
db: pubmed

DP1
type: Protein
entity reference: DP1

Pubmed_11237530
type: PublicationXref
id: 11237530
db: pubmed

DP1
type: Protein
entity reference: DP1

E2F4
type: Protein
entity reference: E2F4

MNAT1
type: ProteinReference
xref: HUGO d pr69 MNAT1

HUGO c gn179 UBB
type: RelationshipXref
id: UBB
db: HGNC

DP2
type: Protein
entity reference: DP2

Pubmed_7681363
type: PublicationXref
id: 7681363
db: pubmed

HUGO c pr138 E2F1
type: RelationshipXref
id: E2F1
db: HGNC

Pubmed_16135806
type: PublicationXref
id: 16135806
db: pubmed

HUGO c gn42 CSDA
type: RelationshipXref
id: CSDA
db: HGNC

HUGO c gn118 BTRC
type: RelationshipXref
id: BTRC
db: HGNC

Pubmed_16792505
type: PublicationXref
id: 16792505
db: pubmed

Pubmed_12478465
type: PublicationXref
id: 12478465
db: pubmed

E2F4
type: Protein
entity reference: E2F4

HUGO c gn79 CDKN2C
type: RelationshipXref
id: CDKN2C
db: HGNC

Pubmed_15713665
type: PublicationXref
id: 15713665
db: pubmed

Pubmed_15464731
type: PublicationXref
id: 15464731
db: pubmed

HUGO c gn109 FGFR1
type: RelationshipXref
id: FGFR1
db: HGNC

HUGO a gn94 CASP9
type: RelationshipXref
id: CASP9
db: HGNC

HUGO e pr155 TP53
type: RelationshipXref
id: TP53
db: HGNC

PLAU
type: DnaRegionReference
xref: HUGO c gn143 PLAU

UBB
type: DnaRegion
entity reference: UBB

Tubulin__alpha_1A
type: DnaRegion
entity reference: Tubulin__alpha_1A

TRIM55
type: DnaRegion
entity reference: TRIM55

TYMS
type: DnaRegion
entity reference: TYMS

WWOX
type: DnaRegion
entity reference: WWOX

ZNF83
type: DnaRegion
entity reference: ZNF83

ZNF451
type: DnaRegion
entity reference: ZNF451

WDR36
type: DnaRegion
entity reference: WDR36

Homo sapiens
type: BioSource

CyclinE
type: ProteinReference
xref: HUGO d pr15 CCNE1
xref: HUGO d pr15 CCNE2

SPAG7
type: DnaRegion
entity reference: SPAG7

Pubmed_16782892
type: PublicationXref
id: 16782892
db: pubmed

HUGO c p24 CCNA2
type: RelationshipXref
id: CCNA2
db: HGNC

HUGO d pr242 WEE1
type: RelationshipXref
id: WEE1
db: HGNC

Pubmed_12214268
type: PublicationXref
id: 12214268
db: pubmed

HUGO c p24 CCNA1
type: RelationshipXref
id: CCNA1
db: HGNC

SRPR
type: DnaRegion
entity reference: SRPR

SSR4
type: DnaRegion
entity reference: SSR4

THEM2
type: DnaRegion
entity reference: THEM2

TP53INP1
type: DnaRegion
entity reference: TP53INP1

SUZ12
type: DnaRegion
entity reference: SUZ12

STMN1
type: DnaRegion
entity reference: STMN1

HUGO d pr239 CCND3
type: RelationshipXref
id: CCND3
db: HGNC

TOP2A
type: DnaRegion
entity reference: TOP2A

HUGO d pr239 CCND2
type: RelationshipXref
id: CCND2
db: HGNC

UHRF1
type: DnaRegion
entity reference: UHRF1

HUGO d pr239 CCND1
type: RelationshipXref
id: CCND1
db: HGNC

TP53BP2
type: DnaRegion
entity reference: TP53BP2

HUGO c p15 SIN3B
type: RelationshipXref
id: SIN3B
db: HGNC

TOPBP1
type: DnaRegion
entity reference: TOPBP1

NRP1
type: DnaRegion
entity reference: NRP1

PLAU
type: DnaRegion
entity reference: PLAU

Pubmed_15140942
type: PublicationXref
id: 15140942
db: pubmed

p53
type: Protein
entity reference: p53
feature: c s381 c rs1 phosphorylated

NBS1
type: Protein
entity reference: NBS1

CBX5
type: DnaRegionReference
xref: HUGO c gn65 CBX5

p53
type: Protein
entity reference: p53
feature: c s382 c rs1 phosphorylated
feature: c s382 c rs2 phosphorylated

HUGO e gn81 CCNE1
type: RelationshipXref
id: CCNE1
db: HGNC

HUGO e gn135 CDKN1B
type: RelationshipXref
id: CDKN1B
db: HGNC

SLC3A2
type: DnaRegion
entity reference: SLC3A2

module_P27KIP
type: Pathway
pathway component: c2 c re289
pathway component: c re169
pathway component: c0 c re298
pathway component: c4 c re289
pathway component: c1 c re289
pathway component: c1 c re92
pathway component: c0 c re175
pathway component: c0 c re174
pathway component: c0 c re178
pathway component: c0 c re179
pathway component: c3 c re289
pathway component: c re196
pathway component: c2 c re92
pathway component: c re298
pathway component: c re171
pathway component: c0 c re92
pathway component: c re174
pathway component: c2 c re298
pathway component: c re179
pathway component: c0 c re269
pathway component: c1 c re298
pathway component: c re178
pathway component: c re175
pathway component: c1 c re179
pathway component: c re270
pathway component: c1 c re178
pathway component: c re92
pathway component: c re269
pathway component: c0 c re169
pathway component: c3 c re92
pathway component: c3 c re298
pathway component: c re181
pathway component: c re289
pathway component: c re180
pathway component: c0 c re289
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

SLC25A14
type: DnaRegion
entity reference: SLC25A14

SNX19
type: DnaRegion
entity reference: SNX19

SOAT2
type: DnaRegion
entity reference: SOAT2

ECE1
type: DnaRegion
entity reference: ECE1

p27KIP1
type: DnaRegion
entity reference: p27KIP1

FOXO3
type: DnaRegion
entity reference: FOXO3

SIVA1
type: DnaRegion
entity reference: SIVA1

HUGO d pr70 CDK7
type: RelationshipXref
id: CDK7
db: HGNC

FOXO1
type: DnaRegion
entity reference: FOXO1

CyclinE
type: DnaRegion
entity reference: CyclinE

TK1
type: DnaRegion
entity reference: TK1

CHEK1
type: Protein
entity reference: CHEK1
feature: c s392 c rs1 phosphorylated
feature: c s392 c rs2 phosphorylated

CHEK1
type: Protein
entity reference: CHEK1

ATM
type: Protein
entity reference: ATM
feature: c s390 c rs1 phosphorylated

p73
type: DnaRegion
entity reference: p73

UDG1A
type: DnaRegion
entity reference: UDG1A

SKP2
type: DnaRegion
entity reference: SKP2

TERT
type: DnaRegion
entity reference: TERT

Pubmed_12459251
type: PublicationXref
id: 12459251
db: pubmed

DUSP2
type: DnaRegion
entity reference: DUSP2

Pubmed_11883315
type: PublicationXref
id: 11883315
db: pubmed

MCM8
type: DnaRegion
entity reference: MCM8

miR_17_92
type: DnaRegion
entity reference: miR_17_92

CDK2_CyclinA__p130
type: Complex
component: CyclinA__at_Nucleus
component: CDK2_at_Nucleus
component: p130__pho_at_Nucleus

CDK2_CyclinA__p107
type: Complex
component: p107__at_Nucleus
component: CyclinA__at_Nucleus
component: CDK2_at_Nucleus

DP1__E2F1_PCAF
type: Complex
component: E2F1_Lys_ace_at_Nucleus
component: PCAF__at_Nucleus
component: DP1__at_Nucleus

HUGO a gn67 FOXO3
type: RelationshipXref
id: FOXO3
db: HGNC

DP1__E2F6
type: Complex
component: E2F6_at_Nucleus
component: DP1__at_Nucleus

p130__pho_at_Nucleus
type: Protein
entity reference: p130
feature: c s1491 c rs1 phosphorylated

p107__at_Nucleus
type: Protein
entity reference: p107

ATM_NBS1
type: Complex
component: NBS1__pho_at_Nucleus
component: ATM_Ser_1981_pho_at_Nucleus

BAF250__DP1__E2F1_HDAC1_RB1_SUV39H1
type: Complex
component: BAF250__at_Nucleus
component: SUV39H1_at_Nucleus
component: HDAC1_at_Nucleus
component: DP1__at_Nucleus
component: E2F1_at_Nucleus
component: RB1_at_Nucleus

BMI1_MEL_18__PHC1_RING1_RYBP
type: Complex
component: PHC1_at_Nucleus
component: BMI1_at_Nucleus
component: RING1_at_Nucleus
component: MEL_18__at_Nucleus
component: RYBP_at_Nucleus

HUGO e p65 MDM2
type: RelationshipXref
id: MDM2
db: HGNC

RBBP4
type: DnaRegionReference
xref: HUGO c gn63 RBBP4

CDK2_Thr160_pho_at_Nucleus
type: Protein
entity reference: CDK2
feature: c s1489 c rs1 phosphorylated

CyclinE__at_Nucleus
type: Protein
entity reference: CyclinE

TOPBP1
type: ProteinReference
xref: HUGO d pr250 TOPBP1
xref: Pubmed_15140942
xref: Pubmed_12697828

ACTG1
type: DnaRegionReference
xref: HUGO c gn35 ACTG1

CyclinE__at_Nucleus
type: Protein
entity reference: CyclinE

p130__pho_at_Nucleus
type: Protein
entity reference: p130
feature: c s1485 c rs1 phosphorylated

CyclinE1
type: DnaRegionReference
xref: HUGO e gn81 CCNE1

CDK2_Thr160_pho_at_Nucleus
type: Protein
entity reference: CDK2
feature: c s1484 c rs1 phosphorylated

EED
type: ProteinReference
xref: HUGO c p87 EED

Pubmed_10733529
type: PublicationXref
id: 10733529
db: pubmed

PKMYT1
type: ProteinReference
xref: HUGO d pr279 PKMYT1

HUGO c gn80 CCNA2
type: RelationshipXref
id: CCNA2
db: HGNC

HUGO c gn192 PURA
type: RelationshipXref
id: PURA
db: HGNC

CyclinA__at_Nucleus
type: Protein
entity reference: CyclinA

CDK2_at_Nucleus
type: Protein
entity reference: CDK2

p107__at_Nucleus
type: Protein
entity reference: p107

CyclinA__at_Nucleus
type: Protein
entity reference: CyclinA

CDK2_at_Nucleus
type: Protein
entity reference: CDK2

p21CIP1
type: Protein
entity reference: p21CIP1

Pubmed_8741839
type: PublicationXref
id: 8741839
db: pubmed

HUGO c gn117 BARD1
type: RelationshipXref
id: BARD1
db: HGNC

HUGO a pr617 CDK1
type: RelationshipXref
id: CDK1
db: HGNC

Pubmed_15897325
type: PublicationXref
id: 15897325
db: pubmed

HUGO c gn127 E2F8
type: RelationshipXref
id: E2F8
db: HGNC

TK1
type: DnaRegionReference
xref: HUGO c gn130 TK1

ATM
type: DnaRegionReference
xref: HUGO c gn9 ATM

METAP2
type: DnaRegionReference
xref: HUGO c gn103 METAP2

CDC20
type: DnaRegionReference
xref: HUGO d gn76 CDC20

PURALPHA
type: DnaRegion
entity reference: PURALPHA

CDCA4
type: DnaRegion
entity reference: CDCA4

HUGO c gn62 MCM3
type: RelationshipXref
id: MCM3
db: HGNC

CDCA7
type: DnaRegion
entity reference: CDCA7

UXT
type: DnaRegion
entity reference: UXT

Pubmed_1717476
type: PublicationXref
id: 1717476
db: pubmed

BMI1
type: DnaRegion
entity reference: BMI1

BRD7
type: DnaRegion
entity reference: BRD7

RQCD1
type: DnaRegionReference
xref: HUGO c gn107 RQCD1

JMY
type: DnaRegionReference
xref: HUGO c gn25 JMY

FGFR2
type: DnaRegionReference
xref: HUGO c gn45 FGFR2

Pubmed_16984923
type: PublicationXref
id: 16984923
db: pubmed

HUGO d pr244 RBL1
type: RelationshipXref
id: RBL1
db: HGNC

Pubmed_16107498
type: PublicationXref
id: 16107498
db: pubmed

Pubmed_8137237
type: PublicationXref
id: 8137237
db: pubmed

CyclinC
type: ProteinReference
xref: HUGO c p45 CCNC

PPP1R13B
type: DnaRegionReference
xref: HUGO c gn2 PPP1R13B

Pubmed_11520855
type: PublicationXref
id: 11520855
db: pubmed

RPL8
type: DnaRegionReference
xref: HUGO c gn49 RPL8

Pubmed_15024084
type: PublicationXref
id: 15024084
db: pubmed

Pubmed_12077144
type: PublicationXref
id: 12077144
db: pubmed

HUGO e pr109 CDKN2B
type: RelationshipXref
id: CDKN2B
db: HGNC

HUGO c gn123 E2F1
type: RelationshipXref
id: E2F1
db: HGNC

Pubmed_15107615
type: PublicationXref
id: 15107615
db: pubmed

Pubmed_9425340
type: PublicationXref
id: 9425340
db: pubmed

JPH2
type: DnaRegionReference
xref: HUGO c gn120 JPH2

Pubmed_8078588
type: PublicationXref
id: 8078588
db: pubmed

HUGO c gn173 TP53IN91
type: RelationshipXref
id: TP53IN91
db: HGNC

Pubmed_11157749
type: PublicationXref
id: 11157749
db: pubmed

HUGO c gn140 TERT
type: RelationshipXref
id: TERT
db: HGNC

HUGO c p45 CCNC
type: RelationshipXref
id: CCNC
db: HGNC

Pubmed_15798220
type: PublicationXref
id: 15798220
db: pubmed

MEL_18__at_Nucleus
type: Protein
entity reference: MEL_18

E2F1
type: Protein
entity reference: E2F1
feature: c s21 c rs1 phosphorylated
feature: c s21 c rs2 acetylated

p107
type: Protein
entity reference: p107

DP1__E2F1
type: Complex
component: E2F1_Lys_ace_Ser31_pho_at_Nucleus
component: DP1__at_Nucleus

Pubmed_12089160
type: PublicationXref
id: 12089160
db: pubmed

Pubmed_11171983
type: PublicationXref
id: 11171983
db: pubmed

APC_C__CDC20
type: Complex
component: APC_C__at_Nucleus
component: CDC20_pho_at_Nucleus

CDK1
type: Protein
entity reference: CDK1

DP1__E2F1_TOPBP1
type: Complex
component: TOPBP1_at_Nucleus
component: E2F1_Lys_ace_Ser31_pho_at_Nucleus
component: DP1__at_Nucleus

CyclinE
type: Protein
entity reference: CyclinE

CDK1_CyclinB
type: Complex
component: CyclinB__at_Nucleus
component: CDK1_Thr14_pho_at_Nucleus

CDK2_CyclinE__p27KIP1
type: Complex
component: p27KIP1__at_Nucleus
component: CDK2_at_Nucleus
component: CyclinE__at_Nucleus

CDK2_CyclinE
type: Complex
component: CyclinE__at_Nucleus
component: CDK2_Tyr14_pho_Tyr15_pho_at_Nucleus

CDK2_CyclinA__p27KIP1
type: Complex
component: CDK2_at_Nucleus
component: CyclinA__at_Nucleus
component: p27KIP1__at_Nucleus

HUGO c p36 MGA
type: RelationshipXref
id: MGA
db: HGNC

CNAP1
type: DnaRegionReference
xref: HUGO c gn59 NCAPD2

HUGO c gn41 COX4I1
type: RelationshipXref
id: COX4I1
db: HGNC

E2F1
type: Protein
entity reference: E2F1

MGA_at_Nucleus
type: Protein
entity reference: MGA

CDK1_CyclinB
type: Complex
component: CyclinB__at_Nucleus
component: CDK1_Tyr15_pho_Thr14_pho_at_Nucleus

RYBP_at_Nucleus
type: Protein
entity reference: RYBP

CDK1_CyclinB
type: Complex
component: CDK1_Tyr15_pho_at_Nucleus
component: CyclinB__at_Nucleus

CDK1_CyclinB
type: Complex
component: CDK1_at_Nucleus
component: CyclinB__at_Nucleus

CDK6_CyclinD
type: Complex
component: CyclinD__at_Nucleus
component: CDK6_at_Nucleus

CDK1_CyclinB
type: Complex
component: CDK1_Thr161_pho_at_Nucleus
component: CyclinB__at_Nucleus

HDAC1
type: Protein
entity reference: HDAC1

CDK7_CyclinH__MNAT1
type: Complex
component: MNAT1_at_Nucleus
component: CyclinH__at_Nucleus
component: CDK7_Thr170_pho_at_Nucleus

RING1_at_Nucleus
type: Protein
entity reference: RING1

E2F6
type: Protein
entity reference: E2F6

HUGO c gn160 SKP2
type: RelationshipXref
id: SKP2
db: HGNC

CDK6_CyclinD__p27KIP1
type: Complex
component: CyclinD__at_Nucleus
component: CDK6_at_Nucleus
component: p27KIP1__at_Nucleus

CDK7_CyclinH__MNAT1
type: Complex
component: CyclinH__at_Nucleus
component: CDK7_at_Nucleus
component: MNAT1_at_Nucleus

CDK4_CyclinD__p27KIP1
type: Complex
component: CyclinD__at_Nucleus
component: CDK4_at_Nucleus
component: p27KIP1__at_Nucleus

CDK4_CyclinD
type: Complex
component: CyclinD__at_Nucleus
component: CDK4_at_Nucleus

HUGO c p12 E2F8
type: RelationshipXref
id: E2F8
db: HGNC

Pubmed_15494392
type: PublicationXref
id: 15494392
db: pubmed

GSK3_beta
type: ProteinReference
xref: HUGO e pr117 GSK3B

Pubmed_16144839
type: PublicationXref
id: 16144839
db: pubmed

HUGO c gn120 JPH2
type: RelationshipXref
id: JPH2
db: HGNC

CDC37_CDK4
type: Complex
component: CDC37_at_Cytoplasm
component: CDK4_NF_don_at_Cytoplasm

HUGO c gn103 METAP2
type: RelationshipXref
id: METAP2
db: HGNC

CDK4_CyclinD
type: Complex
component: CDK4_at_Cytoplasm
component: CyclinD__Thr286_pho_at_Cytoplasm

CDC37_CDK4_HSP90
type: Complex
component: HSP90__hm2_at_Cytoplasm
component: CDC37_at_Cytoplasm
component: CDK4_at_Cytoplasm

CDK4_CyclinD
type: Complex
component: CyclinD__Thr286_pho_at_Nucleus
component: CDK4_at_Nucleus

CDK6_CyclinD
type: Complex
component: CyclinD__at_Cytoplasm
component: CDK6_at_Cytoplasm

CDK6_p16INK4A
type: Complex
component: CDK6_at_Cytoplasm
component: p16INK4A__at_Cytoplasm

CDK4_p16INK4A
type: Complex
component: p16INK4A__at_Cytoplasm
component: CDK4_at_Cytoplasm

CDK4_p15INK4B
type: Complex
component: p15INK4B__at_Cytoplasm
component: CDK4_at_Cytoplasm

CDK4_CyclinD
type: Complex
component: CyclinD__at_Cytoplasm
component: CDK4_at_Cytoplasm

CDC37_HSP90
type: Complex
component: CDC37_at_Cytoplasm
component: HSP90__hm2_at_Cytoplasm

CLSPN
type: DnaRegionReference
xref: HUGO c gn114 CLSPN

MYCN
type: DnaRegionReference
xref: HUGO c gn152 MYCN

Pubmed_8618861
type: PublicationXref
id: 8618861
db: pubmed

Caspase3
type: DnaRegionReference
xref: HUGO a gn93 CASP3

Pubmed_15195143
type: PublicationXref
id: 15195143
db: pubmed

CDK6_p15INK4B
type: Complex
component: p15INK4B__at_Cytoplasm
component: CDK6_at_Cytoplasm

CDK1_CyclinB
type: Complex
component: CDK1_at_Cytoplasm
component: CyclinB__at_Cytoplasm

E2F1
type: DnaRegionReference
xref: HUGO c gn123 E2F1

CDK1_CyclinB
type: Complex
component: CDK1_Thr14_pho_at_Cytoplasm
component: CyclinB__at_Cytoplasm

CDK1_CyclinB
type: Complex
component: CDK1_Tyr15_pho_Thr14_pho_at_Cytoplasm
component: CyclinB__at_Cytoplasm

CDK6_at_Nucleus
type: Protein
entity reference: CDK6

CyclinD__at_Nucleus
type: Protein
entity reference: CyclinD

CDK6_CyclinD__p21CIP1
type: Complex
component: CDK6_at_Nucleus
component: CyclinD__at_Nucleus
component: p21CIP1__at_Nucleus

p21CIP1__at_Nucleus
type: Protein
entity reference: p21CIP1

CDK1_CyclinB
type: Complex
component: CDK1_Tyr15_pho_at_Cytoplasm
component: CyclinB__at_Cytoplasm

PCNA_p21CIP1
type: Complex
component: p21CIP1__at_Nucleus
component: PCNA_at_Nucleus

c2 c re64
type: Catalysis
controlled: c re64
control type: ACTIVATION
controller: PCAF
comment: CDTYPE:CATALYSIS

PSMA4
type: DnaRegionReference
xref: HUGO c gn93 PSMA4

NRP1
type: DnaRegionReference
xref: HUGO c gn158 NRP1

CDT1
type: DnaRegionReference
xref: HUGO c gn89 CDT1

p21CIP1__at_Nucleus
type: Protein
entity reference: p21CIP1

Pubmed_11274364
type: PublicationXref
id: 11274364
db: pubmed

CyclinD__at_Nucleus
type: Protein
entity reference: CyclinD

00394
type: UnificationXref
id: MOD:00394
db: MOD

MYBL2
type: DnaRegionReference
xref: HUGO c gn83 MYBL2

MCM3
type: DnaRegionReference
xref: HUGO c gn62 MCM3

MLH1
type: DnaRegionReference
xref: HUGO c gn102 MLH1

KPNA2
type: DnaRegionReference
xref: HUGO c gn68 KPNA2

HUGO c gn34 ACTN4
type: RelationshipXref
id: ACTN4
db: HGNC

CDK4_at_Nucleus
type: Protein
entity reference: CDK4

CDK4_CyclinD__p21CIP1
type: Complex
component: p21CIP1__at_Nucleus
component: CyclinD__at_Nucleus
component: CDK4_at_Nucleus

CDK2_Thr160_pho_at_Nucleus
type: Protein
entity reference: CDK2
feature: c s786 c rs1 phosphorylated

CDK2_CyclinE__p21CIP1
type: Complex
component: p21CIP1__at_Nucleus
component: CDK2_Thr160_pho_at_Nucleus
component: CyclinE__at_Nucleus

CyclinE__at_Nucleus
type: Protein
entity reference: CyclinE

CDK2_CyclinA__p21CIP1
type: Complex
component: CyclinA__at_Nucleus
component: p21CIP1__at_Nucleus
component: CDK2_Thr160_pho_at_Nucleus

EXOSC8
type: DnaRegionReference
xref: HUGO c gn87 EXOSC8

SRPR
type: DnaRegionReference
xref: HUGO c gn168 SRPR

HUGO d gn82 BUB1
type: RelationshipXref
id: BUB1
db: HGNC

c0 c re330
type: Catalysis
controlled: c re330
control type: ACTIVATION
controller: CDK1_CyclinB
comment: CDTYPE:CATALYSIS

STMN1
type: DnaRegionReference
xref: HUGO c gn171 STMN1

c3 c re92
type: Catalysis
controlled: c re92
control type: ACTIVATION
controller: CDK6_CyclinD__p21CIP1
comment: CDTYPE:CATALYSIS

CyclinA__at_Nucleus
type: Protein
entity reference: CyclinA

p21CIP1__at_Nucleus
type: Protein
entity reference: p21CIP1

p27KIP1
type: ProteinReference
xref: HUGO e pr114 CDKN1B

Pubmed_10030670
type: PublicationXref
id: 10030670
db: pubmed

CyclinB__at_Nucleus
type: Protein
entity reference: CyclinB

Pubmed_12438307
type: PublicationXref
id: 12438307
db: pubmed

CDK1_CyclinB__p21CIP1
type: Complex
component: CDK1_Thr161_pho_at_Nucleus
component: p21CIP1__at_Nucleus
component: CyclinB__at_Nucleus

HUGO c gn159 DUSP2
type: RelationshipXref
id: DUSP2
db: HGNC

TYMS
type: DnaRegionReference
xref: HUGO c gn182 TYMS

Pubmed_9836640
type: PublicationXref
id: 9836640
db: pubmed

CDK1_Thr161_pho_at_Nucleus
type: Protein
entity reference: CDK1
feature: c s799 c rs1 phosphorylated

Pubmed_1828290
type: PublicationXref
id: 1828290
db: pubmed

BMI1
type: DnaRegionReference
xref: HUGO e gn118 BMI1

MDM2
type: ProteinReference
xref: Pubmed_15024084
xref: HUGO e p65 MDM2

HUGO c gn93 PSMA4
type: RelationshipXref
id: PSMA4
db: HGNC

c0 c re323
type: Catalysis
controlled: c re323
control type: ACTIVATION
controller: CDK2_CyclinE
comment: CDTYPE:CATALYSIS

Pubmed_8428594
type: PublicationXref
id: 8428594
db: pubmed

c2 c re92
type: Catalysis
controlled: c re92
control type: ACTIVATION
controller: CDK4_CyclinD__p21CIP1
comment: CDTYPE:CATALYSIS

c0 c re329
type: Catalysis
controlled: c re329
control type: ACTIVATION
controller: WEE1
comment: CDTYPE:CATALYSIS

Pubmed_15838517
type: PublicationXref
id: 15838517
db: pubmed

Pubmed_15838516
type: PublicationXref
id: 15838516
db: pubmed

RPL32
type: DnaRegionReference
xref: HUGO c gn50 RPL32

Pubmed_12411508
type: PublicationXref
id: 12411508
db: pubmed

ZNF83
type: DnaRegionReference
xref: HUGO c gn184 ZNF83

HUGO c gn32 PNRC2
type: RelationshipXref
id: PNRC2
db: HGNC

c0 c re317
type: Catalysis
controlled: c re317
control type: ACTIVATION
controller: TFIIH
comment: CDTYPE:CATALYSIS

c2 c re132
type: Catalysis
controlled: c re132
control type: ACTIVATION
controller: ATR
comment: CDTYPE:CATALYSIS

c0 c re310
type: Catalysis
controlled: c re310
control type: ACTIVATION
controller: CDK7_CyclinH__MNAT1
comment: CDTYPE:CATALYSIS

Pubmed_15470680
type: PublicationXref
id: 15470680
db: pubmed

HUGO c p9 E2F5
type: RelationshipXref
id: E2F5
db: HGNC

HUGO c gn96 PLK1
type: RelationshipXref
id: PLK1
db: HGNC

HUGO d gn76 CDC20
type: RelationshipXref
id: CDC20
db: HGNC

HUGO c gn116 ACR
type: RelationshipXref
id: ACR
db: HGNC

Pubmed_15574337
type: PublicationXref
id: 15574337
db: pubmed

RB1_pho_at_Nucleus
type: Protein
entity reference: RB1
feature: c s90 c rs1 phosphorylated

E2F1_at_Nucleus
type: Protein
entity reference: E2F1

BAF250__at_Nucleus
type: Protein
entity reference: BAF250

DP1__at_Nucleus
type: Protein
entity reference: DP1

HDAC1_at_Nucleus
type: Protein
entity reference: HDAC1

E2F1_at_Nucleus
type: Protein
entity reference: E2F1

RB1_pho_pho_at_Nucleus
type: Protein
entity reference: RB1
feature: c s96 c rs1 phosphorylated
feature: c s96 c rs4 phosphorylated

BAF250__at_Nucleus
type: Protein
entity reference: BAF250

DP1__at_Nucleus
type: Protein
entity reference: DP1

p16INK4A
type: ProteinReference
xref: Pubmed_12210082
xref: HUGO e pr116 CDKN2A
xref: Pubmed_11960696
xref: Pubmed_7606716
xref: Pubmed_15460900

Pubmed_16582100
type: PublicationXref
id: 16582100
db: pubmed

HUGO c gn163 SLC3A2
type: RelationshipXref
id: SLC3A2
db: HGNC

Pubmed_11063929
type: PublicationXref
id: 11063929
db: pubmed

Pubmed_9733514
type: PublicationXref
id: 9733514
db: pubmed

HUGO c gn40 CES4A
type: RelationshipXref
id: CES4A
db: HGNC

Pubmed_9733515
type: PublicationXref
id: 9733515
db: pubmed

DP1__at_Nucleus
type: Protein
entity reference: DP1

Pubmed_1501447
type: PublicationXref
id: 1501447
db: pubmed

SUV39H1_at_Nucleus
type: Protein
entity reference: SUV39H1

HDAC1_at_Nucleus
type: Protein
entity reference: HDAC1

BAF250__at_Nucleus
type: Protein
entity reference: BAF250

EZH2
type: Protein
entity reference: EZH2

EPC1
type: Protein
entity reference: EPC1

DP1__at_Nucleus
type: Protein
entity reference: DP1

E2F1_at_Nucleus
type: Protein
entity reference: E2F1

RB1_at_Nucleus
type: Protein
entity reference: RB1

HUGO c gn2 PPP1R13B
type: RelationshipXref
id: PPP1R13B
db: HGNC

HUGO c gn85 DDX11
type: RelationshipXref
id: DDX11
db: HGNC

HP1gamma__at_Nucleus
type: Protein
entity reference: HP1gamma

MCM5
type: DnaRegionReference
xref: HUGO c gn104 MCM5

HUGO c gn104 MCM5
type: RelationshipXref
id: MCM5
db: HGNC

Pubmed_15456846
type: PublicationXref
id: 15456846
db: pubmed

HUGO c gn177 TOP2A
type: RelationshipXref
id: TOP2A
db: HGNC

BAF250__at_Nucleus
type: Protein
entity reference: BAF250

HP1gamma__at_Nucleus
type: Protein
entity reference: HP1gamma

HUGO c p53 ARID1A
type: RelationshipXref
id: ARID1A
db: HGNC

SUV39H1_at_Nucleus
type: Protein
entity reference: SUV39H1

HDAC1_at_Nucleus
type: Protein
entity reference: HDAC1

E2F4_at_Nucleus
type: Protein
entity reference: E2F4

p107__pho_at_Nucleus
type: Protein
entity reference: p107
feature: c s70 c rs1 phosphorylated

SUV39H1_at_Nucleus
type: Protein
entity reference: SUV39H1

E2F1_at_Nucleus
type: Protein
entity reference: E2F1

RB1_at_Nucleus
type: Protein
entity reference: RB1

HDAC1_at_Nucleus
type: Protein
entity reference: HDAC1

DP2__at_Nucleus
type: Protein
entity reference: DP2

SUV39H1_at_Nucleus
type: Protein
entity reference: SUV39H1

SUV39H1_at_Nucleus
type: Protein
entity reference: SUV39H1

DP2__at_Nucleus
type: Protein
entity reference: DP2

HDAC1_at_Nucleus
type: Protein
entity reference: HDAC1

DP2__at_Nucleus
type: Protein
entity reference: DP2

HUGO c gn153 FOXO1
type: RelationshipXref
id: FOXO1
db: HGNC

POLA
type: DnaRegionReference
xref: HUGO c gn95 POLA2
xref: HUGO c gn95 POLA1

p107__at_Nucleus
type: Protein
entity reference: p107

SERTAD1
type: ProteinReference
xref: Pubmed_11960696
xref: HUGO c p69 SERTAD1

E2F4_at_Nucleus
type: Protein
entity reference: E2F4

HUGO c gn161 SNRPE
type: RelationshipXref
id: SNRPE
db: HGNC

DP1__at_Nucleus
type: Protein
entity reference: DP1

E2F4_at_Nucleus
type: Protein
entity reference: E2F4

E2F1_at_Nucleus
type: Protein
entity reference: E2F1

p130__pho_at_Nucleus
type: Protein
entity reference: p130
feature: c s312 c rs1 phosphorylated

E2F4_at_Nucleus
type: Protein
entity reference: E2F4

Pubmed_15121871
type: PublicationXref
id: 15121871
db: pubmed

DP2__at_Nucleus
type: Protein
entity reference: DP2

E2F1_pho_Lys_ace_at_Nucleus
type: Protein
entity reference: E2F1
feature: c s63 c rs2 acetylated
feature: c s63 c rs1 phosphorylated

DP1__pho_at_Nucleus
type: Protein
entity reference: DP1
feature: c s64 c rs1 phosphorylated

HUGO c gn40 CES5A
type: RelationshipXref
id: CES5A
db: HGNC

HUGO c gn27 MCAM
type: RelationshipXref
id: MCAM
db: HGNC

E2F1_Lys_ace_at_Nucleus
type: Protein
entity reference: E2F1
feature: c s56 c rs2 acetylated

DP1__at_Nucleus
type: Protein
entity reference: DP1

DP1__at_Nucleus
type: Protein
entity reference: DP1

E2F1_at_Nucleus
type: Protein
entity reference: E2F1

RB1_at_Nucleus
type: Protein
entity reference: RB1

E2F1_Lys_ace_at_Nucleus
type: Protein
entity reference: E2F1
feature: c s58 c rs2 acetylated

BAF250__DP1__E2F1_HDAC1_RB1
type: Complex
component: DP1__at_Nucleus
component: E2F1_at_Nucleus
component: RB1_at_Nucleus
component: HDAC1_at_Nucleus
component: BAF250__at_Nucleus

DP1__at_Nucleus
type: Protein
entity reference: DP1

HDAC1_at_Nucleus
type: Protein
entity reference: HDAC1

BAF250__at_Nucleus
type: Protein
entity reference: BAF250

APC_C
type: ProteinReference
xref: HUGO c p82 ANAPC11
xref: HUGO c p82 ANAPC13
xref: HUGO c p82 ANAPC2
xref: HUGO c p82 ANAPC10
xref: HUGO c p82 ANAPC1
xref: HUGO c p82 CDC26
xref: HUGO c p82 ANAPC7
xref: HUGO c p82 ANAPC4
xref: HUGO c p82 CDC23
xref: HUGO c p82 ANAPC5
xref: HUGO c p82 CDC16
xref: HUGO c p82 CDC27

E2F1_at_Nucleus
type: Protein
entity reference: E2F1

DP1__at_Nucleus
type: Protein
entity reference: DP1

E2F4_at_Nucleus
type: Protein
entity reference: E2F4

E2F6_at_Nucleus
type: Protein
entity reference: E2F6

DP1__at_Nucleus
type: Protein
entity reference: DP1

p130__at_Nucleus
type: Protein
entity reference: p130

EPC1_at_Nucleus
type: Protein
entity reference: EPC1

Pubmed_9556498
type: PublicationXref
id: 9556498
db: pubmed

Pubmed_15304485
type: PublicationXref
id: 15304485
db: pubmed

Pubmed_15456871
type: PublicationXref
id: 15456871
db: pubmed

CDK2_CyclinE
type: Complex
component: CyclinE__at_Nucleus
component: CDK2_at_Nucleus

Pubmed_15033491
type: PublicationXref
id: 15033491
db: pubmed

Pubmed_9632134
type: PublicationXref
id: 9632134
db: pubmed

DP1__E2F1
type: Complex
component: E2F1_Lys_ace_at_Nucleus
component: DP1__at_Nucleus

RB1_at_Nucleus
type: Protein
entity reference: RB1

CDK2_CyclinA
type: Complex
component: CDK2_Thr160_pho_at_Nucleus
component: CyclinA__at_Nucleus

DP1__E2F1_RB1
type: Complex
component: DP1__at_Nucleus
component: RB1_pho_pho_pho_at_Nucleus
component: E2F1_at_Nucleus

PHC1_at_Nucleus
type: Protein
entity reference: PHC1

DP1__E2F1_RB1
type: Complex
component: RB1_at_Nucleus
component: E2F1_at_Nucleus
component: DP1__at_Nucleus

BMI1_at_Nucleus
type: Protein
entity reference: BMI1

HUGO c gn194 RBL1
type: RelationshipXref
id: RBL1
db: HGNC

RING1_at_Nucleus
type: Protein
entity reference: RING1

CDK3_CyclinC
type: Complex
component: CyclinC__at_Nucleus
component: CDK3_at_Nucleus

MEL_18__at_Nucleus
type: Protein
entity reference: MEL_18

DP1__E2F1
type: Complex
component: DP1__at_Nucleus
component: E2F1_at_Nucleus

DP2__at_Nucleus
type: Protein
entity reference: DP2

RYBP_at_Nucleus
type: Protein
entity reference: RYBP

BMI1_at_Nucleus
type: Protein
entity reference: BMI1

DP2
type: Protein
entity reference: DP2

E2F6_at_Nucleus
type: Protein
entity reference: E2F6

BAF250
type: Protein
entity reference: BAF250
feature: c s335 c rs1 phosphorylated

CDK2_CyclinA
type: Complex
component: CDK2_at_Nucleus
component: CyclinA__at_Nucleus

HUGO d pr126 CHEK2
type: RelationshipXref
id: CHEK2
db: HGNC

MDM2_p53
type: Complex
component: MDM2_at_Nucleus
component: p53__at_Nucleus

MDM2_p14ARF
type: Complex
component: p14ARF__at_Nucleus
component: MDM2_at_Nucleus

DP1__p14ARF
type: Complex
component: DP1__at_Nucleus
component: p14ARF__at_Nucleus

DIRAS3
type: DnaRegionReference
xref: HUGO c gn75 DIRAS3

E2F8
type: Protein
entity reference: E2F8

E2F1_p14ARF
type: Complex
component: p14ARF__at_Nucleus
component: E2F1_at_Nucleus

PHC1_at_Nucleus
type: Protein
entity reference: PHC1

DP1__E2F1_PCAF
type: Complex
component: PCAF__at_Nucleus
component: E2F1_pho_Lys_ace_at_Nucleus
component: DP1__pho_at_Nucleus

HUGO c gn143 PLAU
type: RelationshipXref
id: PLAU
db: HGNC

DP1__E2F1
type: Complex
component: E2F1_Lys_ace_Ser364_pho_at_Nucleus
component: DP1__at_Nucleus

MCL1
type: DnaRegionReference
xref: HUGO a gn4 MCL1

CDK4_CyclinD__p27KIP1
type: Complex
component: CyclinD__at_Nucleus
component: CDK4_Thr172_pho_at_Nucleus
component: p27KIP1__at_Nucleus

Pubmed_12766152
type: PublicationXref
id: 12766152
db: pubmed

CDK6_CyclinD__p27KIP1
type: Complex
component: p27KIP1__at_Nucleus
component: CyclinD__at_Nucleus
component: CDK6_Thr_pho_at_Nucleus

CDK2_CyclinE
type: Complex
component: CDK2_Thr160_pho_at_Nucleus
component: CyclinE__at_Nucleus

CDK4
type: Protein
entity reference: CDK4

CDK2_CyclinE
type: Complex
component: CyclinE__Thr380_pho_at_Nucleus
component: CDK2_Thr160_pho_at_Nucleus

CyclinA
type: Protein
entity reference: CyclinA

CDK2
type: Protein
entity reference: CDK2

CDK6
type: Protein
entity reference: CDK6

CyclinD
type: Protein
entity reference: CyclinD

APC_C__at_Nucleus
type: Protein
entity reference: APC_C

CDC20_pho_at_Nucleus
type: Protein
entity reference: CDC20
feature: c s224 c rs1 phosphorylated

APC_C__at_Nucleus
type: Protein
entity reference: APC_C

HUGO e gn112 MYC
type: RelationshipXref
id: MYC
db: HGNC

SIVA1
type: DnaRegionReference
xref: HUGO a gn86 SIVA1

p300
type: Protein
entity reference: p300

CBP
type: Protein
entity reference: CBP

SUV39H1
type: Protein
entity reference: SUV39H1

HUGO c gn25 JMY
type: RelationshipXref
id: JMY
db: HGNC

module_CDC25
type: Pathway
pathway component: c0 c re258
pathway component: c0 c re239
pathway component: c0 c re219
pathway component: c0 c re237
pathway component: c re217
pathway component: c re330
pathway component: c re219
pathway component: c0 c re233
pathway component: c0 c re195
pathway component: c re213
pathway component: c0 c re217
pathway component: c re258
pathway component: c re233
pathway component: c re237
pathway component: c1 c re258
pathway component: c re239
pathway component: c re195
pathway component: c re227
pathway component: c re225
pathway component: c0 c re225
pathway component: c0 c re330
pathway component: c0 c re227
pathway component: c re241
pathway component: c re264
pathway component: c re265
pathway component: c0 c re241
pathway component: c1 c re195
pathway component: c1 c re265
pathway component: c0 c re265
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

CyclinE__at_Nucleus
type: Protein
entity reference: CyclinE

ATP5J
type: DnaRegionReference
xref: HUGO c gn36 ATP5J

CDK2_Tyr14_pho_Tyr15_pho_at_Nucleus
type: Protein
entity reference: CDK2
feature: c s216 c rs2 phosphorylated
feature: c s216 c rs3 phosphorylated

CyclinE__Thr380_pho_at_Nucleus
type: Protein
entity reference: CyclinE
feature: c s219 c rs2 phosphorylated

CDK2_Thr160_pho_at_Nucleus
type: Protein
entity reference: CDK2
feature: c s218 c rs1 phosphorylated

CDK2_at_Nucleus
type: Protein
entity reference: CDK2

DP1__at_Nucleus
type: Protein
entity reference: DP1

Pubmed_10778858
type: PublicationXref
id: 10778858
db: pubmed

Pubmed_15105433
type: PublicationXref
id: 15105433
db: pubmed

HUGO e pr16 KAT2B
type: RelationshipXref
id: KAT2B
db: HGNC

Pubmed_16775416
type: PublicationXref
id: 16775416
db: pubmed

Pubmed_7629134
type: PublicationXref
id: 7629134
db: pubmed

PCNA_at_Nucleus
type: Protein
entity reference: PCNA

MDM2_at_Nucleus
type: Protein
entity reference: MDM2

p53__at_Nucleus
type: Protein
entity reference: p53

CDK2_at_Nucleus
type: Protein
entity reference: CDK2

CyclinA__at_Nucleus
type: Protein
entity reference: CyclinA

HUGO c gn45 FGFR2
type: RelationshipXref
id: FGFR2
db: HGNC

CyclinD__at_Nucleus
type: Protein
entity reference: CyclinD

CDK6_at_Nucleus
type: Protein
entity reference: CDK6

Pubmed_12836612
type: PublicationXref
id: 12836612
db: pubmed

PBK
type: DnaRegionReference
xref: HUGO c gn97 PBK

HUGO e pr112 CDK6
type: RelationshipXref
id: CDK6
db: HGNC

DP1
type: Protein
entity reference: DP1
feature: c s240 c rs1 phosphorylated

Pubmed_15105421
type: PublicationXref
id: 15105421
db: pubmed

CyclinE__at_Nucleus
type: Protein
entity reference: CyclinE

HUGO c p87 EED
type: RelationshipXref
id: EED
db: HGNC

CyclinD__at_Nucleus
type: Protein
entity reference: CyclinD

CyclinD__at_Nucleus
type: Protein
entity reference: CyclinD

CDK4_Thr172_pho_at_Nucleus
type: Protein
entity reference: CDK4
feature: c s253 c rs1 phosphorylated

E2F1_at_Nucleus
type: Protein
entity reference: E2F1

CDK4_at_Nucleus
type: Protein
entity reference: CDK4

phosphorylated
type: SequenceModificationVocabulary
xref: 00696

Pubmed_9843217
type: PublicationXref
id: 9843217
db: pubmed

Caspase8
type: DnaRegionReference
xref: HUGO a gn90 CASP8

CDK6_Thr_pho_at_Nucleus
type: Protein
entity reference: CDK6
feature: c s250 c rs1 phosphorylated

Pubmed_11158323
type: PublicationXref
id: 11158323
db: pubmed

Pubmed_9372959
type: PublicationXref
id: 9372959
db: pubmed

CyclinD__at_Nucleus
type: Protein
entity reference: CyclinD

DBF4
type: DnaRegionReference
xref: HUGO c gn17 DBF4

HUGO c gn17 DBF4
type: RelationshipXref
id: DBF4
db: HGNC

Pubmed_15706352
type: PublicationXref
id: 15706352
db: pubmed

HUGO e gn109 CCND3
type: RelationshipXref
id: CCND3
db: HGNC

CDK1_Tyr15_pho_at_Cytoplasm
type: Protein
entity reference: CDK1
feature: c s268 c rs2 phosphorylated

CyclinB__at_Cytoplasm
type: Protein
entity reference: CyclinB

E2F6_at_Nucleus
type: Protein
entity reference: E2F6

Pubmed_7606716
type: PublicationXref
id: 7606716
db: pubmed

CyclinD3
type: DnaRegion
entity reference: CyclinD3

E2F1
type: Protein
entity reference: E2F1
feature: c s266 c rs1 phosphorylated

p107
type: Protein
entity reference: p107
feature: c s265 c rs1 phosphorylated

HUGO c gn186 WDR36
type: RelationshipXref
id: WDR36
db: HGNC

CyclinA2
type: DnaRegion
entity reference: CyclinA2

ATP5J
type: DnaRegion
entity reference: ATP5J

Pubmed_17178835
type: PublicationXref
id: 17178835
db: pubmed

APAF1
type: DnaRegion
entity reference: APAF1

ACTN4
type: DnaRegion
entity reference: ACTN4

ACTG1
type: DnaRegion
entity reference: ACTG1

CBX5
type: DnaRegion
entity reference: CBX5

BCL2L11
type: DnaRegion
entity reference: BCL2L11

BBC3
type: DnaRegion
entity reference: BBC3

AXIN2
type: DnaRegion
entity reference: AXIN2

HUGO c gn126 E2F7
type: RelationshipXref
id: E2F7
db: HGNC

E2F6_at_Nucleus
type: Protein
entity reference: E2F6

MGA_at_Nucleus
type: Protein
entity reference: MGA

MAX_at_Nucleus
type: Protein
entity reference: MAX

DP1__at_Nucleus
type: Protein
entity reference: DP1

APAF1
type: DnaRegionReference
xref: HUGO a gn30 APAF1

Pubmed_17482685
type: PublicationXref
id: 17482685
db: pubmed

CyclinE
type: DnaRegionReference
xref: HUGO d gn71 CCNE1
xref: HUGO d gn71 CCNE2

BAT8__at_Nucleus
type: Protein
entity reference: BAT8

MGA_at_Nucleus
type: Protein
entity reference: MGA

DP1__at_Nucleus
type: Protein
entity reference: DP1

Pubmed_15126619
type: PublicationXref
id: 15126619
db: pubmed

BAF250
type: Protein
entity reference: BAF250

HUGO c gn187 UXT
type: RelationshipXref
id: UXT
db: HGNC

MAX_at_Nucleus
type: Protein
entity reference: MAX

HUGO c gn70 CCNB2
type: RelationshipXref
id: CCNB2
db: HGNC

p21CIP1
type: DnaRegion
entity reference: p21CIP1

CDK1
type: DnaRegion
entity reference: CDK1

carboxylesterase
type: DnaRegion
entity reference: carboxylesterase

p18INK4C
type: DnaRegion
entity reference: p18INK4C

HUGO c gn9 ATM
type: RelationshipXref
id: ATM
db: HGNC

EED
type: DnaRegion
entity reference: EED

COX4I1
type: DnaRegion
entity reference: COX4I1

EZH2
type: DnaRegion
entity reference: EZH2

HUGO c gn29 MYB
type: RelationshipXref
id: MYB
db: HGNC

HUGO e pr122 CDK2
type: RelationshipXref
id: CDK2
db: HGNC

HUGO d gn61 BRCA1
type: RelationshipXref
id: BRCA1
db: HGNC

EHMT1_at_Nucleus
type: Protein
entity reference: EHMT1

HUGO c gn119 HOXA3
type: RelationshipXref
id: HOXA3
db: HGNC

Pubmed_10498883
type: PublicationXref
id: 10498883
db: pubmed

BAT8__at_Nucleus
type: Protein
entity reference: BAT8

HP1gamma__at_Nucleus
type: Protein
entity reference: HP1gamma

DP1__at_Nucleus
type: Protein
entity reference: DP1

E2F6_at_Nucleus
type: Protein
entity reference: E2F6

MGA_at_Nucleus
type: Protein
entity reference: MGA

E2F6_at_Nucleus
type: Protein
entity reference: E2F6

BARD1
type: DnaRegionReference
xref: Pubmed_1510543
xref: HUGO c gn117 BARD1

MAX_at_Nucleus
type: Protein
entity reference: MAX

HUGO c gn71 PFKFB2
type: RelationshipXref
id: PFKFB2
db: HGNC

HUGO c gn71 PFKFB1
type: RelationshipXref
id: PFKFB1
db: HGNC

DP1__at_Nucleus
type: Protein
entity reference: DP1

HUGO c gn71 PFKFB4
type: RelationshipXref
id: PFKFB4
db: HGNC

HUGO c gn166 SOAT2
type: RelationshipXref
id: SOAT2
db: HGNC

HUGO c gn71 PFKFB3
type: RelationshipXref
id: PFKFB3
db: HGNC

HSP90
type: ProteinReference
xref: HUGO a pr590 HSP90AA1

FHIT
type: DnaRegion
entity reference: FHIT

FGFR2
type: DnaRegion
entity reference: FGFR2

EXOSC8
type: DnaRegion
entity reference: EXOSC8

EIF2AK2
type: DnaRegion
entity reference: EIF2AK2

DNMT1
type: DnaRegion
entity reference: DNMT1

DDX11
type: DnaRegion
entity reference: DDX11

CNAP1
type: DnaRegion
entity reference: CNAP1

Pubmed_12004135
type: PublicationXref
id: 12004135
db: pubmed

CDT1
type: DnaRegion
entity reference: CDT1

Pubmed_15123636
type: PublicationXref
id: 15123636
db: pubmed

HUGO c p37 CBX3
type: RelationshipXref
id: CBX3
db: HGNC

MYC
type: DnaRegion
entity reference: MYC

GAB2
type: DnaRegion
entity reference: GAB2

EZH2_at_Nucleus
type: Protein
entity reference: EZH2

EPC1_at_Nucleus
type: Protein
entity reference: EPC1

EPC1_at_Nucleus
type: Protein
entity reference: EPC1

E2F6_at_Nucleus
type: Protein
entity reference: E2F6

EED_at_Nucleus
type: Protein
entity reference: EED

HUGO c pr9 E2F7
type: RelationshipXref
id: E2F7
db: HGNC

CSDA
type: DnaRegion
entity reference: CSDA

ESR1
type: DnaRegion
entity reference: ESR1

PCNA
type: ProteinReference
xref: Pubmed_12814430
xref: HUGO d pr12 PCNA
xref: Pubmed_11355576

FSHR
type: DnaRegion
entity reference: FSHR

DIRAS3
type: DnaRegion
entity reference: DIRAS3

MYBL2
type: DnaRegion
entity reference: MYBL2

HRK
type: DnaRegion
entity reference: HRK

HUGO a pr662 MAX
type: RelationshipXref
id: MAX
db: HGNC

E2F4_cofactors
type: PhysicalEntity
comment: This is a CellDesigner UNKNOWN entity.

E2F8
type: DnaRegion
entity reference: E2F8

CHEK2
type: DnaRegion
entity reference: CHEK2

E2F6_cofactors
type: PhysicalEntity
comment: This is a CellDesigner UNKNOWN entity.

RAD51AP1
type: DnaRegion
entity reference: RAD51AP1

MRPL27
type: DnaRegion
entity reference: MRPL27

MSH2
type: DnaRegion
entity reference: MSH2

EED
type: DnaRegionReference
xref: HUGO c gn10 EED

MTHFD1
type: DnaRegion
entity reference: MTHFD1

NEK2
type: DnaRegion
entity reference: NEK2

MYCN
type: DnaRegion
entity reference: MYCN

PTGS2
type: DnaRegion
entity reference: PTGS2

MAD2
type: DnaRegion
entity reference: MAD2

MCM5
type: DnaRegion
entity reference: MCM5

METAP2
type: DnaRegion
entity reference: METAP2

MLH1
type: DnaRegion
entity reference: MLH1

SKP2
type: DnaRegionReference
xref: HUGO c gn160 SKP2

c3 c re289
type: Catalysis
controlled: c re289
control type: ACTIVATION
controller: CDK6_CyclinD__p21CIP1
comment: CDTYPE:CATALYSIS

carboxylesterase
type: DnaRegionReference
xref: HUGO c gn40 CES5A
xref: HUGO c gn40 CES4A
xref: HUGO c gn40 CES1
xref: HUGO c gn40 CES2
xref: HUGO c gn40 CES3

CDC25A
type: DnaRegion
entity reference: CDC25A

TP53BP2
type: DnaRegionReference
xref: HUGO c gn174 TP53BP1

BRCA1
type: DnaRegion
entity reference: BRCA1

Caspase9
type: DnaRegion
entity reference: Caspase9

HUGO c gn171 STMN1
type: RelationshipXref
id: STMN1
db: HGNC

HUGO e pr133 E2F1
type: RelationshipXref
id: E2F1
db: HGNC

CDC14A
type: ProteinReference
xref: HUGO d pr309 CDC14A

HUGO c gn51 MCM6
type: RelationshipXref
id: MCM6
db: HGNC

POLA
type: DnaRegion
entity reference: POLA

PRKDC
type: DnaRegion
entity reference: PRKDC

PLK1
type: DnaRegion
entity reference: PLK1

AURKB
type: DnaRegion
entity reference: AURKB

BIRC5
type: DnaRegion
entity reference: BIRC5

PSMA4
type: DnaRegion
entity reference: PSMA4

RAD54L
type: DnaRegion
entity reference: RAD54L

Pubmed_15190204
type: PublicationXref
id: 15190204
db: pubmed

UHRF1
type: DnaRegionReference
xref: HUGO c gn178 UHRF1

E2F8_cofactors
type: PhysicalEntity
comment: This is a CellDesigner UNKNOWN entity.

E2F7_cofactors
type: PhysicalEntity
comment: This is a CellDesigner UNKNOWN entity.

HUGO c gn151 H19
type: RelationshipXref
id: H19
db: HGNC

RPL8
type: DnaRegion
entity reference: RPL8

CyclinE1
type: DnaRegion
entity reference: CyclinE1

CyclinB2
type: DnaRegion
entity reference: CyclinB2

H19
type: DnaRegion
entity reference: H19

PPARG
type: DnaRegion
entity reference: PPARG

PPP1R13B
type: DnaRegion
entity reference: PPP1R13B

RPA2
type: DnaRegion
entity reference: RPA2

CDK3
type: ProteinReference
xref: HUGO c p46 CDK3

SLC3A2
type: DnaRegionReference
xref: HUGO c gn163 SLC3A2

Pubmed_90001421
type: PublicationXref
id: 90001421
db: pubmed

Pubmed_15711575
type: PublicationXref
id: 15711575
db: pubmed

ESR1
type: DnaRegionReference
xref: HUGO c gn91 ESR1

PTGS2
type: DnaRegionReference
xref: HUGO c gn46 PTGS2

MELK
type: DnaRegion
entity reference: MELK

CyclinB1
type: DnaRegion
entity reference: CyclinB1

CDC6
type: DnaRegion
entity reference: CDC6

Caspase7
type: DnaRegion
entity reference: Caspase7

Caspase8
type: DnaRegion
entity reference: Caspase8

RBM25
type: DnaRegion
entity reference: RBM25

BCL2
type: DnaRegion
entity reference: BCL2

Pubmed_10827953
type: PublicationXref
id: 10827953
db: pubmed

CDK2
type: ProteinReference
xref: HUGO e pr122 CDK2

PFKFB
type: DnaRegion
entity reference: PFKFB

E2F5_cofactors
type: PhysicalEntity
comment: This is a CellDesigner UNKNOWN entity.

c3 c re298
type: Catalysis
controlled: c re298
control type: ACTIVATION
controller: CDK6_CyclinD__p21CIP1
comment: CDTYPE:CATALYSIS

HUGO c gn168 SRPR
type: RelationshipXref
id: SRPR
db: HGNC

Pubmed_12149244
type: PublicationXref
id: 12149244
db: pubmed

UDG1A
type: DnaRegionReference
xref: HUGO c gn195 UNG

Pubmed_17135268
type: PublicationXref
id: 17135268
db: pubmed

SNX19
type: DnaRegionReference
xref: HUGO c gn165 SNX19

SERPINE1
type: DnaRegion
entity reference: SERPINE1

BARD1
type: DnaRegion
entity reference: BARD1

ACR
type: DnaRegion
entity reference: ACR

CHEK1
type: DnaRegion
entity reference: CHEK1

BTRC
type: DnaRegion
entity reference: BTRC

CSTF3
type: DnaRegion
entity reference: CSTF3

CSTF1
type: DnaRegion
entity reference: CSTF1

FBXO5
type: DnaRegion
entity reference: FBXO5

DRF1
type: DnaRegion
entity reference: DRF1

BUB1
type: DnaRegionReference
xref: HUGO d gn82 BUB1

CyclinB1
type: DnaRegionReference
xref: HUGO d gn75 CCNB1

Pubmed_16123593
type: PublicationXref
id: 16123593
db: pubmed

HUGO d pr309 CDC14A
type: RelationshipXref
id: CDC14A
db: HGNC

JPH2
type: DnaRegion
entity reference: JPH2

HOXA3
type: DnaRegion
entity reference: HOXA3

ECE1
type: DnaRegionReference
xref: HUGO c gn146 ECE1

FGFR1
type: DnaRegion
entity reference: FGFR1

c0 c re1045
type: Catalysis
controlled: c re1045
controller: E2F1_alone
comment: CDTYPE:UNKNOWN_POSITIVE_INFLUENCE

DBF4
type: DnaRegion
entity reference: DBF4

RQCD1
type: DnaRegion
entity reference: RQCD1

RFC5
type: DnaRegion
entity reference: RFC5

KNTC2
type: DnaRegion
entity reference: KNTC2

HUGO c gn36 ATP5J
type: RelationshipXref
id: ATP5J
db: HGNC

DHFR
type: DnaRegion
entity reference: DHFR

CYC1
type: DnaRegion
entity reference: CYC1

Caspase3
type: DnaRegion
entity reference: Caspase3

HUGO c p1 E2F4
type: RelationshipXref
id: E2F4
db: HGNC

miR_17_92
type: DnaRegionReference
xref: HUGO c gn157 MIR17HG

HUGO e p47 ATM
type: RelationshipXref
id: ATM
db: HGNC

CDC25A
type: DnaRegionReference
xref: HUGO d gn79 CDC25A

Pubmed_12789259
type: PublicationXref
id: 12789259
db: pubmed

HUGO c gn24 ISYNA1
type: RelationshipXref
id: ISYNA1
db: HGNC

Pubmed_11484059
type: PublicationXref
id: 11484059
db: pubmed

Pubmed_11390642
type: PublicationXref
id: 11390642
db: pubmed

E2F1
type: ProteinReference
xref: HUGO e pr133 E2F1

ATR
type: ProteinReference
xref: HUGO d pr90 ATR

NPAT
type: DnaRegionReference
xref: HUGO c gn77 NPAT

HUGO c gn174 TP53BP1
type: RelationshipXref
id: TP53BP1
db: HGNC

COX4I1
type: DnaRegionReference
xref: HUGO c gn41 COX4I1

HUGO e pr531 PPP1CC
type: RelationshipXref
id: PPP1CC
db: HGNC

HUGO e pr531 PPP1CB
type: RelationshipXref
id: PPP1CB
db: HGNC

HUGO e pr531 PPP1CA
type: RelationshipXref
id: PPP1CA
db: HGNC

HUGO d pr90 ATR
type: RelationshipXref
id: ATR
db: HGNC

HUGO c p33 PHC1
type: RelationshipXref
id: PHC1
db: HGNC

Pubmed_11960696
type: PublicationXref
id: 11960696
db: pubmed

SUV39H1
type: ProteinReference
xref: HUGO c p52 SUV39H1

HUGO c gn69 POLD3
type: RelationshipXref
id: POLD3
db: HGNC

Pubmed_11799067
type: PublicationXref
id: 11799067
db: pubmed

HUGO c gn72 CDC6
type: RelationshipXref
id: CDC6
db: HGNC

DP2__E2F4
type: Complex
component: E2F4_at_Nucleus
component: DP2__at_Nucleus

Pubmed_10548110
type: PublicationXref
id: 10548110
db: pubmed

c0 c re276
type: Catalysis
controlled: c re276
control type: ACTIVATION
controller: p14ARF
comment: CDTYPE:CATALYSIS

DP2__E2F4
type: Complex
component: E2F4_at_Cytoplasm
component: DP2__at_Cytoplasm

DP1__E2F6
type: Complex
component: E2F6_at_Cytoplasm
component: DP1__at_Cytoplasm

DP2__E2F4_p130
type: Complex
component: E2F4_at_Nucleus
component: p130__at_Nucleus
component: DP2__at_Nucleus

DP2__E2F4_p130
type: Complex
component: E2F4_at_Cytoplasm
component: DP2__at_Cytoplasm
component: p130__at_Cytoplasm

HDAC1_SIN3B
type: Complex
component: SIN3B_at_Nucleus
component: HDAC1_at_Nucleus

Tubulin__alpha_1A
type: DnaRegionReference
xref: HUGO c gn180 TUBA1A

HUGO d pr69 MNAT1
type: RelationshipXref
id: MNAT1
db: HGNC

HUGO c pr84 CDKN3
type: RelationshipXref
id: CDKN3
db: HGNC

DP2__E2F6
type: Complex
component: E2F6_at_Cytoplasm
component: DP2__at_Cytoplasm

MAX_MGA
type: Complex
component: MGA_at_Nucleus
component: MAX_at_Nucleus

BAF250__DP1__E2F1_HDAC1_RB1
type: Complex
component: BAF250__at_Nucleus
component: DP1__at_Nucleus
component: HDAC1_at_Nucleus
component: RB1_pho_at_Nucleus
component: E2F1_at_Nucleus

BAF250__DP1__E2F1_HDAC1_HP1gamma__RB1_SUV39H1
type: Complex
component: SUV39H1_at_Nucleus
component: HDAC1_at_Nucleus
component: BAF250__at_Nucleus
component: DP1__at_Nucleus
component: E2F1_at_Nucleus
component: RB1_at_Nucleus
component: HP1gamma__at_Nucleus

HP1gamma__SUV39H1
type: Complex
component: HP1gamma__at_Nucleus
component: SUV39H1_at_Nucleus

Pubmed_12566389
type: PublicationXref
id: 12566389
db: pubmed

DP2__E2F4_HDAC1_SIN3B_SUV39H1_p130
type: Complex
component: SUV39H1_at_Nucleus
component: DP2__at_Nucleus
component: HDAC1_at_Nucleus
component: E2F4_at_Nucleus
component: SIN3B_at_Nucleus
component: p130__pho_at_Nucleus

DP2__E2F4_HDAC1_SIN3B_SUV39H1_p130
type: Complex
component: HDAC1_at_Nucleus
component: DP2__at_Nucleus
component: SUV39H1_at_Nucleus
component: E2F4_at_Nucleus
component: SIN3B_at_Nucleus
component: p130__at_Nucleus

Pubmed_10859163
type: PublicationXref
id: 10859163
db: pubmed

Pubmed_10859164
type: PublicationXref
id: 10859164
db: pubmed

E2F8
type: ProteinReference
xref: HUGO c p12 E2F8

DP2__E2F4_p107
type: Complex
component: DP2__at_Nucleus
component: p107__at_Nucleus
component: E2F4_at_Nucleus

c0 c re289
type: Catalysis
controlled: c re289
control type: ACTIVATION
controller: CDK2_CyclinE
comment: CDTYPE:CATALYSIS

c0 c re292
type: Catalysis
controlled: c re292
control type: ACTIVATION
controller: HDAC1
comment: CDTYPE:CATALYSIS

p15INK4B__at_Cytoplasm
type: Protein
entity reference: p15INK4B

p15INK4B__at_Cytoplasm
type: Protein
entity reference: p15INK4B

c1 c re621
type: Catalysis
controlled: c re621
control type: ACTIVATION
controller: CHEK2
comment: CDTYPE:CATALYSIS

c1 c re622
type: Catalysis
controlled: c re622
control type: ACTIVATION
controller: ATR
comment: CDTYPE:CATALYSIS

p15INK4B
type: Protein
entity reference: p15INK4B

DP1__E2F6_EPC1
type: Complex
component: E2F6_at_Nucleus
component: DP1__at_Nucleus
component: EPC1_at_Nucleus

c0 c re298
type: Catalysis
controlled: c re298
control type: ACTIVATION
controller: CDK6_CyclinD__p27KIP1
comment: CDTYPE:CATALYSIS

CDKN3
type: Protein
entity reference: CDKN3

HUGO c gn61 DHFR
type: RelationshipXref
id: DHFR
db: HGNC

HUGO c gn16 SERPINE1
type: RelationshipXref
id: SERPINE1
db: HGNC

HUGO c gn44 EIF2AK2
type: RelationshipXref
id: EIF2AK2
db: HGNC

p21CIP1__at_Nucleus
type: Protein
entity reference: p21CIP1

module_APOPTOSIS_ENTRY
type: Pathway
pathway component: c re164
pathway component: c1 c re621
pathway component: c0 c re276
pathway component: c1 c re622
pathway component: c re281
pathway component: c0 c re195
pathway component: c1 c re132
pathway component: c0 c re135
pathway component: c re142
pathway component: c0 c re132
pathway component: c0 c re157
pathway component: c1 c re135
pathway component: c0 c re130
pathway component: c0 c re158
pathway component: c re130
pathway component: c0 c re159
pathway component: c re276
pathway component: c re275
pathway component: c re195
pathway component: c re278
pathway component: c re159
pathway component: c re157
pathway component: c re158
pathway component: c re271
pathway component: c re273
pathway component: c re135
pathway component: c re132
pathway component: c re268
pathway component: c re141
pathway component: c re623
pathway component: c2 c re132
pathway component: c re624
pathway component: c0 c re141
pathway component: c0 c re142
pathway component: c re265
pathway component: c re266
pathway component: c0 c re622
pathway component: c1 c re195
pathway component: c re621
pathway component: c0 c re621
pathway component: c re622
pathway component: c1 c re265
pathway component: c0 c re265
pathway component: c re160
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

DP2__E2F6
type: Complex
component: E2F6_at_Nucleus
component: DP2__at_Nucleus

BAT8__DP1__E2F6_EHMT1_HP1gamma__MAX_MGA
type: Complex
component: BAT8__at_Nucleus
component: HP1gamma__at_Nucleus
component: DP1__at_Nucleus
component: E2F6_at_Nucleus
component: MGA_at_Nucleus
component: MAX_at_Nucleus
component: EHMT1_at_Nucleus

HUGO c gn107 RQCD1
type: RelationshipXref
id: RQCD1
db: HGNC

E2F2
type: DnaRegionReference
xref: HUGO c gn122 E2F2

DP1__E2F6_MAX_MGA
type: Complex
component: MGA_at_Nucleus
component: MAX_at_Nucleus
component: DP1__at_Nucleus
component: E2F6_at_Nucleus

DP2__E2F4_p107
type: Complex
component: E2F4_at_Nucleus
component: p107__pho_at_Nucleus
component: DP2__at_Nucleus

HUGO e gn118 BMI1
type: RelationshipXref
id: BMI1
db: HGNC

HUGO c gn176 TOPBP1
type: RelationshipXref
id: TOPBP1
db: HGNC

DP1__E2F6_EED_EPC1_EZH2_SIN3B
type: Complex
component: EED_at_Nucleus
component: EPC1_at_Nucleus
component: DP1__at_Nucleus
component: E2F6_at_Nucleus
component: EZH2_at_Nucleus
component: SIN3B_at_Nucleus

DP1__E2F6_EED_EPC1_EZH2
type: Complex
component: EZH2_at_Nucleus
component: EPC1_at_Nucleus
component: EED_at_Nucleus
component: E2F6_at_Nucleus
component: DP1__at_Nucleus

BMI1_DP2__E2F6_MEL_18__PHC1_RING1_RYBP
type: Complex
component: PHC1_at_Nucleus
component: MEL_18__at_Nucleus
component: DP2__at_Nucleus
component: RYBP_at_Nucleus
component: BMI1_at_Nucleus
component: E2F6_at_Nucleus
component: RING1_at_Nucleus

p14ARF
type: DnaRegionReference
xref: HUGO c gn82 CDKN2A

module_WEE
type: Pathway
pathway component: c re232
pathway component: c re218
pathway component: c0 c re195
pathway component: c re329
pathway component: c0 c re232
pathway component: c re195
pathway component: c1 c re195
pathway component: c0 c re218
pathway component: c0 c re329
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

c0 c re1272
type: Catalysis
controlled: c re1272
control type: ACTIVATION
controller: CDK2_CyclinA
comment: CDTYPE:CATALYSIS

CDK1
type: Protein
entity reference: CDK1

HUGO c gn58 MELK
type: RelationshipXref
id: MELK
db: HGNC

Pubmed_15731768
type: PublicationXref
id: 15731768
db: pubmed

HRK
type: DnaRegionReference
xref: HUGO a gn148 HRK

HUGO c p28 EPC1
type: RelationshipXref
id: EPC1
db: HGNC

p27KIP1__at_Nucleus
type: Protein
entity reference: p27KIP1

CDC25C
type: ProteinReference
xref: HUGO d pr116 CDC25C
xref: Pubmed_12478465

p27KIP1__at_Nucleus
type: Protein
entity reference: p27KIP1

p21CIP1
type: Protein
entity reference: p21CIP1
feature: c s655 c rs2 phosphorylated

p27KIP1__at_Nucleus
type: Protein
entity reference: p27KIP1

p130
type: ProteinReference
xref: Pubmed_12006580
xref: Pubmed_11157749
xref: HUGO c p2 RBL2
xref: Pubmed_15838516
xref: Pubmed_11756542

FSHR
type: DnaRegionReference
xref: HUGO c gn86 FSHR

p27KIP1__at_Nucleus
type: Protein
entity reference: p27KIP1

p27KIP1__at_Nucleus
type: Protein
entity reference: p27KIP1

p27KIP1__at_Nucleus
type: Protein
entity reference: p27KIP1

HUGO a gn53 BCL2
type: RelationshipXref
id: BCL2
db: HGNC

p27KIP1
type: Protein
entity reference: p27KIP1

p27KIP1
type: Protein
entity reference: p27KIP1
feature: c s646 c rs1 phosphorylated

p27KIP1
type: Protein
entity reference: p27KIP1
feature: c s647 c rs2 phosphorylated

p27KIP1
type: Protein
entity reference: p27KIP1
feature: c s648 c rs2 phosphorylated

Pubmed_15590326
type: PublicationXref
id: 15590326
db: pubmed

Pubmed_10373560
type: PublicationXref
id: 10373560
db: pubmed

RRM1
type: DnaRegionReference
xref: HUGO c gn1 RRM1

p53
type: ProteinReference
xref: HUGO e pr155 TP53

HUGO c gn65 CBX5
type: RelationshipXref
id: CBX5
db: HGNC

RFC5
type: DnaRegionReference

SIN3B_at_Nucleus
type: Protein
entity reference: SIN3B

SIN3B_at_Nucleus
type: Protein
entity reference: SIN3B

SIN3B_at_Nucleus
type: Protein
entity reference: SIN3B

CDK4
type: Protein
entity reference: CDK4

HUGO c gn94 PRKDC
type: RelationshipXref
id: PRKDC
db: HGNC

SIN3B
type: Protein
entity reference: SIN3B

SIN3B_at_Nucleus
type: Protein
entity reference: SIN3B

HUGO c gn122 E2F2
type: RelationshipXref
id: E2F2
db: HGNC

TOPBP1
type: Protein
entity reference: TOPBP1

TOPBP1_at_Nucleus
type: Protein
entity reference: TOPBP1

Pubmed_15536069
type: PublicationXref
id: 15536069
db: pubmed

TFIIH
type: Protein
entity reference: TFIIH

DP2
type: ProteinReference
xref: HUGO c p19 TFDP2

CDK1
type: Protein
entity reference: CDK1
feature: c s633 c rs1 phosphorylated

PCAF
type: Protein
entity reference: PCAF

PCAF__at_Nucleus
type: Protein
entity reference: PCAF

PCAF__at_Nucleus
type: Protein
entity reference: PCAF

CDK2_Thr160_pho_at_Nucleus
type: Protein
entity reference: CDK2
feature: c s627 c rs1 phosphorylated

CyclinA__at_Nucleus
type: Protein
entity reference: CyclinA

E2F1
type: Protein
entity reference: E2F1
feature: c s629 c rs5 phosphorylated

DDX11
type: DnaRegionReference
xref: HUGO c gn85 DDX11

HUGO c p82 ANAPC11
type: RelationshipXref
id: ANAPC11
db: HGNC

CyclinE__at_Nucleus
type: Protein
entity reference: CyclinE

CDK2_at_Nucleus
type: Protein
entity reference: CDK2

HUGO c pr83 GTF2H1
type: RelationshipXref
id: GTF2H1
db: HGNC

HUGO c p82 ANAPC13
type: RelationshipXref
id: ANAPC13
db: HGNC

CDK2_Thr160_pho_at_Nucleus
type: Protein
entity reference: CDK2
feature: c s215 c rs1 phosphorylated

HUGO c pr83 GTF2H2
type: RelationshipXref
id: GTF2H2
db: HGNC

CyclinE__at_Nucleus
type: Protein
entity reference: CyclinE

MNAT1_at_Nucleus
type: Protein
entity reference: MNAT1

Pubmed_7799941
type: PublicationXref
id: 7799941
db: pubmed

CyclinH__at_Nucleus
type: Protein
entity reference: CyclinH

HUGO c p82 ANAPC10
type: RelationshipXref
id: ANAPC10
db: HGNC

CDKN3
type: ProteinReference
xref: HUGO c pr84 CDKN3
xref: Pubmed_11355576

NEK2
type: DnaRegionReference
xref: HUGO c gn98 NEK2

CDK7_Thr170_pho_at_Nucleus
type: Protein
entity reference: CDK7
feature: c s209 c rs1 phosphorylated

Pubmed_10385618
type: PublicationXref
id: 10385618
db: pubmed

Pubmed_9106657
type: PublicationXref
id: 9106657
db: pubmed

MNAT1_at_Nucleus
type: Protein
entity reference: MNAT1

ATM
type: Protein
entity reference: ATM

CHEK2
type: Protein
entity reference: CHEK2

CyclinH__at_Nucleus
type: Protein
entity reference: CyclinH

CDK7_at_Nucleus
type: Protein
entity reference: CDK7

CDK1_Tyr15_pho_at_Nucleus
type: Protein
entity reference: CDK1
feature: c s202 c rs2 phosphorylated

c1 c re298
type: Catalysis
controlled: c re298
control type: ACTIVATION
controller: CDK4_CyclinD__p27KIP1
comment: CDTYPE:CATALYSIS

CyclinB__at_Nucleus
type: Protein
entity reference: CyclinB

CDK1_Thr14_pho_at_Cytoplasm
type: Protein
entity reference: CDK1
feature: c s200 c rs3 phosphorylated

HUGO c gn181 TRIM55
type: RelationshipXref
id: TRIM55
db: HGNC

BRD7
type: DnaRegionReference
xref: HUGO c gn196 BRD7

HUGO c gn66 GMNN
type: RelationshipXref
id: GMNN
db: HGNC

DRF1
type: DnaRegionReference
xref: HUGO c gn111 DBF4B

E2F6
type: ProteinReference
xref: HUGO c p10 E2F6

HUGO a gn93 CASP3
type: RelationshipXref
id: CASP3
db: HGNC

c0 c re219
type: Catalysis
controlled: c re219
control type: ACTIVATION
controller: CDC25C
comment: CDTYPE:CATALYSIS

HUGO c gn11 PCNA
type: RelationshipXref
id: PCNA
db: HGNC

c1 c re289
type: Catalysis
controlled: c re289
control type: ACTIVATION
controller: CDK6_CyclinD__p27KIP1
comment: CDTYPE:CATALYSIS

MSH2
type: DnaRegionReference
xref: HUGO c gn100 MSH2

Pubmed_14532106
type: PublicationXref
id: 14532106
db: pubmed

c0 c re217
type: Catalysis
controlled: c re217
control type: ACTIVATION
controller: CDC25C
comment: CDTYPE:CATALYSIS

c0 c re218
type: Catalysis
controlled: c re218
control type: ACTIVATION
controller: WEE1
comment: CDTYPE:CATALYSIS

HUGO c gn22 FHIT
type: RelationshipXref
id: FHIT
db: HGNC

c0 c re216
type: Catalysis
controlled: c re216
control type: ACTIVATION
controller: CDK7_CyclinH__MNAT1
comment: CDTYPE:CATALYSIS

Pubmed_8441401
type: PublicationXref
id: 8441401
db: pubmed

HUGO c p42 EHMT1
type: RelationshipXref
id: EHMT1
db: HGNC

p53
type: DnaRegionReference
xref: HUGO a gn63 TP53

HUGO c gn82 CDKN2A
type: RelationshipXref
id: CDKN2A
db: HGNC

TOPBP1
type: DnaRegionReference
xref: HUGO c gn176 TOPBP1

c0 c re224
type: Catalysis
controlled: c re224
control type: ACTIVATION
controller: PKMYT1
comment: CDTYPE:CATALYSIS

c0 c re225
type: Catalysis
controlled: c re225
control type: ACTIVATION
controller: CDC25C
comment: CDTYPE:CATALYSIS

c0 c re226
type: Catalysis
controlled: c re226
control type: ACTIVATION
controller: PKMYT1
comment: CDTYPE:CATALYSIS

c0 c re227
type: Catalysis
controlled: c re227
control type: ACTIVATION
controller: CDC25C
comment: CDTYPE:CATALYSIS

Pubmed_15867357
type: PublicationXref
id: 15867357
db: pubmed

Pubmed_16360315
type: PublicationXref
id: 16360315
db: pubmed

Pubmed_15867358
type: PublicationXref
id: 15867358
db: pubmed

HUGO c pr83 GTF2H5
type: RelationshipXref
id: GTF2H5
db: HGNC

HUGO c pr83 GTF2H4
type: RelationshipXref
id: GTF2H4
db: HGNC

HUGO c pr83 GTF2H3
type: RelationshipXref
id: GTF2H3
db: HGNC

HUGO c gn77 NPAT
type: RelationshipXref
id: NPAT
db: HGNC

FOXO3
type: DnaRegionReference
xref: HUGO a gn67 FOXO3

Pubmed_15313206
type: PublicationXref
id: 15313206
db: pubmed

HUGO a pr791 FZR1
type: RelationshipXref
id: FZR1
db: HGNC

c0 c re239
type: Catalysis
controlled: c re239
control type: ACTIVATION
controller: CDC25C
comment: CDTYPE:CATALYSIS

c0 c re238
type: Catalysis
controlled: c re238
control type: ACTIVATION
controller: PKMYT1
comment: CDTYPE:CATALYSIS

c0 c re237
type: Catalysis
controlled: c re237
control type: ACTIVATION
controller: CDC25C
comment: CDTYPE:CATALYSIS

c0 c re236
type: Catalysis
controlled: c re236
control type: ACTIVATION
controller: PKMYT1
comment: CDTYPE:CATALYSIS

c0 c re233
type: Catalysis
controlled: c re233
control type: ACTIVATION
controller: CDC25C
comment: CDTYPE:CATALYSIS

Pubmed_8861947
type: PublicationXref
id: 8861947
db: pubmed

AURKB
type: DnaRegionReference
xref: HUGO c gn5 AURKB

Pubmed_16158053
type: PublicationXref
id: 16158053
db: pubmed

c0 c re232
type: Catalysis
controlled: c re232
control type: ACTIVATION
controller: WEE1
comment: CDTYPE:CATALYSIS

HUGO c gn91 ESR1
type: RelationshipXref
id: ESR1
db: HGNC

CyclinD
type: ProteinReference
xref: HUGO d pr239 CCND3
xref: HUGO d pr239 CCND2
xref: HUGO d pr239 CCND1

WWOX
type: DnaRegionReference
xref: HUGO c gn183 WWOX

c0 c re248
type: Catalysis
controlled: c re248
control type: ACTIVATION
controller: GSK3_beta
comment: CDTYPE:CATALYSIS

c0 c re247
type: Catalysis
controlled: c re247
control type: INHIBITION
controller: SERTAD1
comment: CDTYPE:INHIBITION

p107
type: ProteinReference
xref: Pubmed_11157749
xref: Pubmed_12006580
xref: Pubmed_15838516
xref: HUGO d pr244 RBL1

Pubmed_16131838
type: PublicationXref
id: 16131838
db: pubmed

HUGO c gn195 UNG
type: RelationshipXref
id: UNG
db: HGNC

BIRC5
type: DnaRegionReference
xref: HUGO a gn9 BIRC5

c0 c re241
type: Catalysis
controlled: c re241
control type: ACTIVATION
controller: CDC25C
comment: CDTYPE:CATALYSIS

HUGO c gn185 ZNF451
type: RelationshipXref
id: ZNF451
db: HGNC

c0 c re258
type: Catalysis
controlled: c re258
control type: ACTIVATION
controller: CDK2_CyclinA
comment: CDTYPE:CATALYSIS

Pubmed_9001210
type: PublicationXref
id: 9001210
db: pubmed

c0 c re257
type: Catalysis
controlled: c re257
control type: ACTIVATION
controller: APC_C__CDC20
comment: CDTYPE:CATALYSIS

c0 c re255
type: Catalysis
controlled: c re255
control type: ACTIVATION
controller: CDK1_CyclinB
comment: CDTYPE:CATALYSIS

HUGO c gn156 MCM8
type: RelationshipXref
id: MCM8
db: HGNC

HUGO c gn191 CDCA7
type: RelationshipXref
id: CDCA7
db: HGNC

Pubmed_11857079
type: PublicationXref
id: 11857079
db: pubmed

Pubmed_8440392
type: PublicationXref
id: 8440392
db: pubmed

Pubmed_7736585
type: PublicationXref
id: 7736585
db: pubmed

Pubmed_15985428
type: PublicationXref
id: 15985428
db: pubmed

BCL2
type: DnaRegionReference
xref: HUGO a gn53 BCL2

HUGO c gn99 MTHFD1
type: RelationshipXref
id: MTHFD1
db: HGNC

c0 c re251
type: Catalysis
controlled: c re251
control type: ACTIVATION
controller: CDKN3
comment: CDTYPE:CATALYSIS

c0 c re269
type: Catalysis
controlled: c re269
control type: ACTIVATION
controller: AKT1
comment: CDTYPE:CATALYSIS

Pubmed_16331253
type: PublicationXref
id: 16331253
db: pubmed

Pubmed_15766563
type: PublicationXref
id: 15766563
db: pubmed

HUGO c gn172 ACOT13
type: RelationshipXref
id: ACOT13
db: HGNC

HUGO c gn114 CLSPN
type: RelationshipXref
id: CLSPN
db: HGNC

Pubmed_11980909
type: PublicationXref
id: 11980909
db: pubmed

DP1
type: ProteinReference
xref: HUGO c p18 TFDP1

c0 c re260
type: Catalysis
controlled: c re260
control type: ACTIVATION
controller: APC_C__CDC20
comment: CDTYPE:CATALYSIS

c0 c re261
type: Catalysis
controlled: c re261
control type: ACTIVATION
controller: CDC14
comment: CDTYPE:CATALYSIS

c0 c re265
type: Catalysis
controlled: c re265
control type: ACTIVATION
controller: CHEK1
comment: CDTYPE:CATALYSIS

Pubmed_12625370
type: PublicationXref
id: 12625370
db: pubmed

HUGO d pr250 TOPBP1
type: RelationshipXref
id: TOPBP1
db: HGNC

BAT8
type: ProteinReference
xref: HUGO c p41 EHMT2

CDK4_at_Cytoplasm
type: Protein
entity reference: CDK4

p16INK4A__at_Cytoplasm
type: Protein
entity reference: p16INK4A

E2F4
type: ProteinReference
xref: HUGO c p1 E2F4

CyclinD__at_Nucleus
type: Protein
entity reference: CyclinD

HUGO c gn49 RPL8
type: RelationshipXref
id: RPL8
db: HGNC

CyclinD__Thr286_pho_at_Nucleus
type: Protein
entity reference: CyclinD
feature: c s169 c rs1 phosphorylated

CDK4_at_Nucleus
type: Protein
entity reference: CDK4

CyclinD__at_Cytoplasm
type: Protein
entity reference: CyclinD

HSP90__hm2_at_Cytoplasm
type: Protein
entity reference: HSP90

CDK4_at_Cytoplasm
type: Protein
entity reference: CDK4

Pubmed_14688249
type: PublicationXref
id: 14688249
db: pubmed

CDK4_at_Cytoplasm
type: Protein
entity reference: CDK4

c1 c re64
type: Catalysis
controlled: c re64
control type: ACTIVATION
controller: CBP
comment: CDTYPE:CATALYSIS

HSP90__hm2_at_Cytoplasm
type: Protein
entity reference: HSP90

CDC37_at_Cytoplasm
type: Protein
entity reference: CDC37

HUGO c gn60 RAD51AP1
type: RelationshipXref
id: RAD51AP1
db: HGNC

Pubmed_15070733
type: PublicationXref
id: 15070733
db: pubmed

CDK4_at_Cytoplasm
type: Protein
entity reference: CDK4

HUGO c gn92 RAD54L
type: RelationshipXref
id: RAD54L
db: HGNC

Pubmed_15279789
type: PublicationXref
id: 15279789
db: pubmed

CDK4_at_Nucleus
type: Protein
entity reference: CDK4

RAD51AP1
type: DnaRegionReference
xref: HUGO c gn60 RAD51AP1

Pubmed_12139485
type: PublicationXref
id: 12139485
db: pubmed

FGFR1
type: DnaRegionReference
xref: HUGO c gn109 FGFR1

CDK3
type: Protein
entity reference: CDK3

CyclinC
type: Protein
entity reference: CyclinC

CyclinD__Thr286_pho_at_Cytoplasm
type: Protein
entity reference: CyclinD
feature: c s171 c rs1 phosphorylated

HUGO d pr116 CDC25C
type: RelationshipXref
id: CDC25C
db: HGNC

TOP2A
type: DnaRegionReference
xref: HUGO c gn177 TOP2A

CDK6
type: ProteinReference
xref: Pubmed_10498883
xref: Pubmed_10385618
xref: HUGO e pr112 CDK6

MGA
type: Protein
entity reference: MGA

CDK1
type: ProteinReference
xref: HUGO a pr617 CDK1

Pubmed_11355576
type: PublicationXref
id: 11355576
db: pubmed

BAT8
type: Protein
entity reference: BAT8

PNRC2
type: DnaRegionReference
xref: HUGO c gn32 PNRC2

EHMT1
type: Protein
entity reference: EHMT1

HUGO c pr139 E2F2
type: RelationshipXref
id: E2F2
db: HGNC

HP1gamma
type: Protein
entity reference: HP1gamma

MAX
type: Protein
entity reference: MAX

E2F2_alone
type: ProteinReference
xref: HUGO c pr139 E2F2

Pubmed_15840442
type: PublicationXref
id: 15840442
db: pubmed

Pubmed_15840440
type: PublicationXref
id: 15840440
db: pubmed

module_E2F1
type: Pathway
pathway component: c0 c re292
pathway component: c re55
pathway component: c1 c re621
pathway component: c0 c re276
pathway component: c1 c re622
pathway component: c0 c re64
pathway component: c0 c re86
pathway component: c re318
pathway component: c re317
pathway component: c re100
pathway component: c re276
pathway component: c re275
pathway component: c re64
pathway component: c re291
pathway component: c0 c re98
pathway component: c re292
pathway component: c re60
pathway component: c re86
pathway component: c re87
pathway component: c1 c re64
pathway component: c0 c re2
pathway component: c re139
pathway component: c re271
pathway component: c0 c re317
pathway component: c re97
pathway component: c re2
pathway component: c re99
pathway component: c re98
pathway component: c2 c re64
pathway component: c0 c re622
pathway component: c re621
pathway component: c0 c re621
pathway component: c re622
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

module_E2F4
type: Pathway
pathway component: c2 c re289
pathway component: c1 c re289
pathway component: c4 c re289
pathway component: c1 c re92
pathway component: c re31
pathway component: c3 c re289
pathway component: c2 c re92
pathway component: c0 c re92
pathway component: c re1275
pathway component: c re1276
pathway component: c re290
pathway component: c re1273
pathway component: c re1274
pathway component: c re197
pathway component: c re223
pathway component: c re222
pathway component: c re92
pathway component: c re95
pathway component: c re94
pathway component: c3 c re92
pathway component: c re96
pathway component: c re288
pathway component: c re289
pathway component: c re91
pathway component: c re8
pathway component: c0 c re289
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

CDC37_at_Cytoplasm
type: Protein
entity reference: CDC37

module_E2F6
type: Pathway
pathway component: c re71
pathway component: c re283
pathway component: c re284
pathway component: c re88
pathway component: c re41
pathway component: c re27
pathway component: c re23
pathway component: c re618
pathway component: c re26
pathway component: c re286
pathway component: c re285
pathway component: c re287
pathway component: c re297
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

PPP1C__at_Nucleus
type: Protein
entity reference: PPP1C

HUGO c gn102 MLH1
type: RelationshipXref
id: MLH1
db: HGNC

Pubmed_17471234
type: PublicationXref
id: 17471234
db: pubmed

CyclinD__at_Nucleus
type: Protein
entity reference: CyclinD

CDK6_at_Nucleus
type: Protein
entity reference: CDK6

CyclinD__at_Cytoplasm
type: Protein
entity reference: CyclinD

CDK6_at_Cytoplasm
type: Protein
entity reference: CDK6

E2F1_Lys_ace_Ser364_pho_at_Nucleus
type: Protein
entity reference: E2F1
feature: c s118 c rs4 phosphorylated
feature: c s118 c rs2 acetylated

RB1
type: ProteinReference
xref: Pubmed_9315635
xref: HUGO a pr653 RB1

HUGO c gn157 MIR17HG
type: RelationshipXref
id: MIR17HG
db: HGNC

DP1__at_Nucleus
type: Protein
entity reference: DP1

DP1__at_Nucleus
type: Protein
entity reference: DP1

Pubmed_11704823
type: PublicationXref
id: 11704823
db: pubmed

CDC37
type: ProteinReference
xref: HUGO c p78 CDC37

WEE1
type: ProteinReference
xref: HUGO d pr242 WEE1

c1 c re258
type: Catalysis
controlled: c re258
control type: ACTIVATION
controller: CDK1_CyclinB
comment: CDTYPE:CATALYSIS

E2F1_Lys_ace_Ser31_pho_at_Nucleus
type: Protein
entity reference: E2F1
feature: c s120 c rs3 phosphorylated
feature: c s120 c rs2 acetylated

DP1__at_Nucleus
type: Protein
entity reference: DP1

E2F1_Lys_ace_Ser31_pho_at_Nucleus
type: Protein
entity reference: E2F1
feature: c s123 c rs2 acetylated
feature: c s123 c rs3 phosphorylated

DP1__at_Nucleus
type: Protein
entity reference: DP1

CDK2_at_Nucleus
type: Protein
entity reference: CDK2

c1 c re257
type: Catalysis
controlled: c re257
control type: ACTIVATION
controller: APC_C__FZR1
comment: CDTYPE:CATALYSIS

CyclinA__at_Nucleus
type: Protein
entity reference: CyclinA

NBS1__pho_at_Nucleus
type: Protein
entity reference: NBS1
feature: c s129 c rs1 phosphorylated

ATM_Ser_1981_pho_at_Nucleus
type: Protein
entity reference: ATM
feature: c s128 c rs1 phosphorylated

HUGO e pr168 EZH2
type: RelationshipXref
id: EZH2
db: HGNC

E2F8
type: DnaRegionReference
xref: HUGO c gn127 E2F8

PLK1
type: DnaRegionReference
xref: HUGO c gn96 PLK1
xref: Pubmed_1510543

Pubmed_12556884
type: PublicationXref
id: 12556884
db: pubmed

CDK6_at_Cytoplasm
type: Protein
entity reference: CDK6

HUGO a gn28 MCM7
type: RelationshipXref
id: MCM7
db: HGNC

CyclinC__at_Nucleus
type: Protein
entity reference: CyclinC

HUGO c gn7 CHEK2
type: RelationshipXref
id: CHEK2
db: HGNC

CDK3_at_Nucleus
type: Protein
entity reference: CDK3

c1 c re265
type: Catalysis
controlled: c re265
control type: ACTIVATION
controller: CHEK2
comment: CDTYPE:CATALYSIS

MDM2_at_Nucleus
type: Protein
entity reference: MDM2

HUGO c gn10 EED
type: RelationshipXref
id: EED
db: HGNC

c1 c re92
type: Catalysis
controlled: c re92
control type: ACTIVATION
controller: CDK4_CyclinD__p27KIP1
comment: CDTYPE:CATALYSIS

Pubmed_8515817
type: PublicationXref
id: 8515817
db: pubmed

HUGO c gn97 PBK
type: RelationshipXref
id: PBK
db: HGNC

E2F4_at_Cytoplasm
type: Protein
entity reference: E2F4

DP2__at_Cytoplasm
type: Protein
entity reference: DP2

E2F6_at_Cytoplasm
type: Protein
entity reference: E2F6

DP2__at_Cytoplasm
type: Protein
entity reference: DP2

p130__at_Cytoplasm
type: Protein
entity reference: p130

GMNN
type: DnaRegionReference
xref: HUGO c gn66 GMNN

p27KIP1
type: DnaRegionReference
xref: HUGO e gn135 CDKN1B

E2F4_at_Nucleus
type: Protein
entity reference: E2F4

p130__at_Nucleus
type: Protein
entity reference: p130

c0 c re2
type: Catalysis
controlled: c re2
control type: ACTIVATION
controller: E2F1
comment: CDTYPE:CATALYSIS

Pubmed_11420722
type: PublicationXref
id: 11420722
db: pubmed

MCM8
type: DnaRegionReference
xref: HUGO c gn156 MCM8

RB1_pho_pho_pho_at_Nucleus
type: Protein
entity reference: RB1
feature: c s115 c rs4 phosphorylated
feature: c s115 c rs1 phosphorylated
feature: c s115 c rs3 phosphorylated

E2F1_at_Nucleus
type: Protein
entity reference: E2F1

Pubmed_12446760
type: PublicationXref
id: 12446760
db: pubmed

E2F6_at_Nucleus
type: Protein
entity reference: E2F6

DP1__at_Nucleus
type: Protein
entity reference: DP1

E2F6_at_Nucleus
type: Protein
entity reference: E2F6

Pubmed_11420729
type: PublicationXref
id: 11420729
db: pubmed

DP2__at_Nucleus
type: Protein
entity reference: DP2

DP2__at_Nucleus
type: Protein
entity reference: DP2

Pubmed_12861053
type: PublicationXref
id: 12861053
db: pubmed

Pubmed_10395539
type: PublicationXref
id: 10395539
db: pubmed

MXD3
type: DnaRegion
entity reference: MXD3

MCM3
type: DnaRegion
entity reference: MCM3

MCL1
type: DnaRegion
entity reference: MCL1

Pubmed_12771133
type: PublicationXref
id: 12771133
db: pubmed

MYB
type: DnaRegion
entity reference: MYB

MCM10
type: DnaRegion
entity reference: MCM10

JMY
type: DnaRegion
entity reference: JMY

HUGO d pr71 CCNH
type: RelationshipXref
id: CCNH
db: HGNC

ISYNA1
type: DnaRegion
entity reference: ISYNA1

MCAM
type: DnaRegion
entity reference: MCAM

LGALS1
type: DnaRegion
entity reference: LGALS1

Pubmed_16181749
type: PublicationXref
id: 16181749
db: pubmed

CyclinB
type: ProteinReference
xref: HUGO c p23 CCNB3
xref: HUGO c p23 CCNB2
xref: HUGO c p23 CCNB1
xref: Pubmed_16123593

GMNN
type: DnaRegion
entity reference: GMNN

HUGO c gn59 NCAPD2
type: RelationshipXref
id: NCAPD2
db: HGNC

Pubmed_11959842
type: PublicationXref
id: 11959842
db: pubmed

Pubmed_12944911
type: PublicationXref
id: 12944911
db: pubmed

KPNA2
type: DnaRegion
entity reference: KPNA2

CDC20
type: DnaRegion
entity reference: CDC20

PPP1C
type: ProteinReference
xref: HUGO e pr531 PPP1CC
xref: HUGO e pr531 PPP1CB
xref: HUGO e pr531 PPP1CA

BUB1
type: DnaRegion
entity reference: BUB1

c0 c re604
type: Catalysis
controlled: c re604
control type: ACTIVATION
controller: AKT1
comment: CDTYPE:CATALYSIS

RBBP8
type: DnaRegion
entity reference: RBBP8

RBBP4
type: DnaRegion
entity reference: RBBP4

PNRC2
type: DnaRegion
entity reference: PNRC2

HUGO e pr116 CDKN2A
type: RelationshipXref
id: CDKN2A
db: HGNC

MGA
type: ProteinReference
xref: HUGO c p36 MGA

PMAIP1
type: DnaRegion
entity reference: PMAIP1

PCNA
type: DnaRegion
entity reference: PCNA

p14ARF
type: DnaRegion
entity reference: p14ARF

NPAT
type: DnaRegion
entity reference: NPAT

TERT
type: DnaRegionReference
xref: HUGO c gn140 TERT

CyclinD3
type: DnaRegionReference
xref: HUGO e gn109 CCND3

Pubmed_11313881
type: PublicationXref
id: 11313881
db: pubmed

E2F6
type: DnaRegion
entity reference: E2F6

E2F_cofactors
type: PhysicalEntity
comment: This is a CellDesigner UNKNOWN entity.

Pubmed_12611887
type: PublicationXref
id: 12611887
db: pubmed

E2F1
type: DnaRegion
entity reference: E2F1

HUGO d pr93 CHEK1
type: RelationshipXref
id: CHEK1
db: HGNC

HUGO c p46 CDK3
type: RelationshipXref
id: CDK3
db: HGNC

acetylated
type: SequenceModificationVocabulary
xref: 00394

MCM6
type: DnaRegion
entity reference: MCM6

MYB
type: DnaRegionReference
xref: HUGO c gn29 MYB

E2F7
type: DnaRegion
entity reference: E2F7

E2F2
type: DnaRegion
entity reference: E2F2

HUGO c gn68 KPNA2
type: RelationshipXref
id: KPNA2
db: HGNC

Pubmed_12781359
type: PublicationXref
id: 12781359
db: pubmed

p18INK4C
type: DnaRegionReference
xref: HUGO c gn79 CDKN2C

c0 c re622
type: Catalysis
controlled: c re622
control type: ACTIVATION
controller: ATM
comment: CDTYPE:CATALYSIS

c0 c re621
type: Catalysis
controlled: c re621
control type: ACTIVATION
controller: CHEK2
comment: CDTYPE:CATALYSIS

UXT
type: DnaRegionReference
xref: HUGO c gn187 UXT

HUGO e pr117 GSK3B
type: RelationshipXref
id: GSK3B
db: HGNC

MAD2
type: DnaRegionReference
xref: HUGO d gn81 MAD2L1

E2F7
type: ProteinReference
xref: HUGO c pr9 E2F7

Pubmed_15037762
type: PublicationXref
id: 15037762
db: pubmed

HUGO c p2 RBL2
type: RelationshipXref
id: RBL2
db: HGNC

Pubmed_11756542
type: PublicationXref
id: 11756542
db: pubmed

HDAC1_at_Nucleus
type: Protein
entity reference: HDAC1

p130
type: Protein
entity reference: p130
feature: c s3 c rs1 phosphorylated

p130
type: Protein
entity reference: p130

EZH2
type: DnaRegionReference
xref: HUGO e gn142 EZH2

RB1
type: Protein
entity reference: RB1

MAX_at_Nucleus
type: Protein
entity reference: MAX

RB1
type: Protein
entity reference: RB1
feature: c s9 c rs3 phosphorylated
feature: c s9 c rs4 phosphorylated
feature: c s9 c rs1 phosphorylated

HUGO c p41 EHMT2
type: RelationshipXref
id: EHMT2
db: HGNC

Pubmed_9278512
type: PublicationXref
id: 9278512
db: pubmed

CSTF3
type: DnaRegionReference
xref: HUGO c gn112 CSTF3

HUGO c gn196 BRD7
type: RelationshipXref
id: BRD7
db: HGNC

CDK1_at_Nucleus
type: Protein
entity reference: CDK1

CyclinB__at_Nucleus
type: Protein
entity reference: CyclinB

CDC37_at_Cytoplasm
type: Protein
entity reference: CDC37

CDK4_at_Cytoplasm
type: Protein
entity reference: CDK4

Pubmed_11959850
type: PublicationXref
id: 11959850
db: pubmed

CDK4_NF_don_at_Cytoplasm
type: Protein
entity reference: CDK4

CDK1_Tyr15_pho_Thr14_pho_at_Cytoplasm
type: Protein
entity reference: CDK1
feature: c s188 c rs3 phosphorylated
feature: c s188 c rs2 phosphorylated

CyclinB__at_Cytoplasm
type: Protein
entity reference: CyclinB

CyclinB__at_Nucleus
type: Protein
entity reference: CyclinB

CDCA4
type: DnaRegionReference
xref: HUGO c gn190 CDCA4

CDC6
type: DnaRegionReference
xref: HUGO c gn72 CDC6

HUGO c p30 RYBP
type: RelationshipXref
id: RYBP
db: HGNC

RRM2
type: DnaRegionReference
xref: HUGO c gn148 RRM2

HUGO c gn15 CDK1
type: RelationshipXref
id: CDK1
db: HGNC

CyclinB__at_Nucleus
type: Protein
entity reference: CyclinB

CyclinB__at_Nucleus
type: Protein
entity reference: CyclinB

CDK1_Thr14_pho_at_Nucleus
type: Protein
entity reference: CDK1
feature: c s195 c rs3 phosphorylated

E2F4_at_Cytoplasm
type: Protein
entity reference: E2F4

CDK1_at_Cytoplasm
type: Protein
entity reference: CDK1

CyclinB__at_Cytoplasm
type: Protein
entity reference: CyclinB

CDK1_Tyr15_pho_Thr14_pho_at_Nucleus
type: Protein
entity reference: CDK1
feature: c s192 c rs3 phosphorylated
feature: c s192 c rs2 phosphorylated

HUGO d pr313 CREBBP
type: RelationshipXref
id: CREBBP
db: HGNC

DP2__at_Cytoplasm
type: Protein
entity reference: DP2

E2F8
type: Complex

CyclinB__at_Cytoplasm
type: Protein
entity reference: CyclinB

EED
type: Protein
entity reference: EED

HUGO e pr15 EP300
type: RelationshipXref
id: EP300
db: HGNC

Pubmed_12015319
type: PublicationXref
id: 12015319
db: pubmed

FZR1
type: Protein
entity reference: FZR1
feature: c s540 c rs1 phosphorylated

CyclinB
type: Protein
entity reference: CyclinB

CDC14
type: Protein
entity reference: CDC14A

c0 c re175
type: Catalysis
controlled: c re175
control type: ACTIVATION
controller: CDK7_CyclinH__MNAT1
comment: CDTYPE:CATALYSIS

PCNA
type: Protein
entity reference: PCNA

c0 c re174
type: Catalysis
controlled: c re174
control type: ACTIVATION
controller: CDK7_CyclinH__MNAT1
comment: CDTYPE:CATALYSIS

c0 c re178
type: Catalysis
controlled: c re178
control type: ACTIVATION
controller: p27KIP1
comment: CDTYPE:CATALYSIS

c0 c re179
type: Catalysis
controlled: c re179
control type: ACTIVATION
controller: p27KIP1
comment: CDTYPE:CATALYSIS

CDC20
type: Protein
entity reference: CDC20
feature: c s536 c rs1 phosphorylated

FZR1
type: Protein
entity reference: FZR1

BMI1
type: ProteinReference
xref: HUGO e pr167 BMI1

HUGO c gn167 SPAG7
type: RelationshipXref
id: SPAG7
db: HGNC

HUGO e pr165 HDAC1
type: RelationshipXref
id: HDAC1
db: HGNC

HUGO c gn111 DBF4B
type: RelationshipXref
id: DBF4B
db: HGNC

AKT1
type: ProteinReference
xref: HUGO e pr404 AKT1

c0 c re188
type: Catalysis
controlled: c re188
control type: ACTIVATION
controller: GSK3_beta
comment: CDTYPE:CATALYSIS

c0 c re186
type: Catalysis
controlled: c re186
control type: ACTIVATION
controller: GSK3_beta
comment: CDTYPE:CATALYSIS

Pubmed_12210082
type: PublicationXref
id: 12210082
db: pubmed

CDC25C
type: Protein
entity reference: CDC25C
feature: c s547 c rs1 phosphorylated
feature: c s547 c rs2 phosphorylated

HUGO c gn98 NEK2
type: RelationshipXref
id: NEK2
db: HGNC

HUGO c gn86 FSHR
type: RelationshipXref
id: FSHR
db: HGNC

Pubmed_11559537
type: PublicationXref
id: 11559537
db: pubmed

Caspase9
type: DnaRegionReference
xref: HUGO a gn94 CASP9

HUGO c gn100 MSH2
type: RelationshipXref
id: MSH2
db: HGNC

c0 c re155
type: Catalysis
controlled: c re155
control type: ACTIVATION
controller: AKT1
comment: CDTYPE:CATALYSIS

HUGO c gn112 CSTF3
type: RelationshipXref
id: CSTF3
db: HGNC

c0 c re157
type: Catalysis
controlled: c re157
control type: ACTIVATION
controller: AKT1
comment: CDTYPE:CATALYSIS

c0 c re158
type: Catalysis
controlled: c re158
control type: ACTIVATION
controller: ATM
comment: CDTYPE:CATALYSIS

c0 c re159
type: Catalysis
controlled: c re159
control type: ACTIVATION
controller: ATM
comment: CDTYPE:CATALYSIS

HUGO d gn84 CHEK1
type: RelationshipXref
id: CHEK1
db: HGNC

Pubmed_15271987
type: PublicationXref
id: 15271987
db: pubmed

HUGO c gn5 AURKB
type: RelationshipXref
id: AURKB
db: HGNC

HUGO d pr12 PCNA
type: RelationshipXref
id: PCNA
db: HGNC

c0 c re165
type: Catalysis
controlled: c re165
control type: INHIBITION
controller: SERTAD1
comment: CDTYPE:INHIBITION

Pubmed_15572025
type: PublicationXref
id: 15572025
db: pubmed

c0 c re169
type: Catalysis
controlled: c re169
control type: ACTIVATION
controller: CDK2_CyclinE
comment: CDTYPE:CATALYSIS

PURALPHA
type: DnaRegionReference
xref: HUGO c gn192 PURA

Pubmed_9670027
type: PublicationXref
id: 9670027
db: pubmed

Pubmed_12748276
type: PublicationXref
id: 12748276
db: pubmed

Pubmed_11231573
type: PublicationXref
id: 11231573
db: pubmed

CyclinA
type: ProteinReference
xref: Pubmed_9736735
xref: HUGO c p24 CCNA2
xref: Pubmed_15558010
xref: Pubmed_16123593
xref: HUGO c p24 CCNA1

Pubmed_15044096
type: PublicationXref
id: 15044096
db: pubmed

HUGO c gn75 DIRAS3
type: RelationshipXref
id: DIRAS3
db: HGNC

Pubmed_15460900
type: PublicationXref
id: 15460900
db: pubmed

MYC
type: DnaRegionReference
xref: HUGO e gn112 MYC

MRPL27
type: DnaRegionReference
xref: HUGO c gn101 MRPL27

Pubmed_12006580
type: PublicationXref
id: 12006580
db: pubmed

HUGO e pr114 CDKN1B
type: RelationshipXref
id: CDKN1B
db: HGNC

HUGO c gn1 RRM1
type: RelationshipXref
id: RRM1
db: HGNC

HUGO c gn170 SUZ12
type: RelationshipXref
id: SUZ12
db: HGNC

PKMYT1
type: Protein
entity reference: PKMYT1
feature: c s503 c rs1 phosphorylated

CDC25C
type: Protein
entity reference: CDC25C

HUGO c gn165 SNX19
type: RelationshipXref
id: SNX19
db: HGNC

ISYNA1
type: DnaRegionReference
xref: HUGO c gn24 ISYNA1

CDC20
type: ProteinReference
xref: HUGO d pr23 CDC20

CyclinD
type: Protein
entity reference: CyclinD
feature: c s523 c rs1 phosphorylated

Pubmed_12766778
type: PublicationXref
id: 12766778
db: pubmed

c0 c re195
type: Catalysis
controlled: c re195
control type: ACTIVATION
controller: CHEK1
comment: CDTYPE:CATALYSIS

HUGO c gn83 MYBL2
type: RelationshipXref
id: MYBL2
db: HGNC

E2F6
type: DnaRegionReference
xref: HUGO c gn125 E2F6

p300
type: ProteinReference
xref: HUGO e pr15 EP300

HUGO c gn46 PTGS2
type: RelationshipXref
id: PTGS2
db: HGNC

HUGO d gn75 CCNB1
type: RelationshipXref
id: CCNB1
db: HGNC

EZH2
type: ProteinReference
xref: HUGO e pr168 EZH2

CDC20
type: Protein
entity reference: CDC20

APC_C
type: Protein
entity reference: APC_C

HUGO e pr111 CDK4
type: RelationshipXref
id: CDK4
db: HGNC

EPC1
type: ProteinReference
xref: HUGO c p28 EPC1

Pubmed_10973490
type: PublicationXref
id: 10973490
db: pubmed

HUGO c p18 TFDP1
type: RelationshipXref
id: TFDP1
db: HGNC

HUGO a pr920 NBN
type: RelationshipXref
id: NBN
db: HGNC

CDK2
type: Protein
entity reference: CDK2
feature: c s528 c rs1 phosphorylated

Pubmed_10688648
type: PublicationXref
id: 10688648
db: pubmed

CyclinE
type: Protein
entity reference: CyclinE
feature: c s529 c rs2 phosphorylated

CHEK2
type: DnaRegionReference
xref: HUGO c gn7 CHEK2

c0 c re64
type: Catalysis
controlled: c re64
control type: ACTIVATION
controller: p300
comment: CDTYPE:CATALYSIS

CDK7
type: ProteinReference
xref: HUGO d pr70 CDK7

RYBP
type: ProteinReference
xref: HUGO c p30 RYBP

Pubmed_9819415
type: PublicationXref
id: 9819415
db: pubmed

TFIIH
type: ProteinReference
xref: HUGO c pr83 GTF2H1
xref: HUGO c pr83 GTF2H2
xref: HUGO c pr83 GTF2H5
xref: HUGO c pr83 GTF2H4
xref: HUGO c pr83 GTF2H2B
xref: HUGO c pr83 GTF2H3
xref: HUGO c pr83 GTF2H2C
xref: HUGO c pr83 GTF2H2D

p21CIP1
type: ProteinReference
xref: Pubmed_9736735
xref: Pubmed_10498883
xref: HUGO e pr115 CDKN1A
xref: Pubmed_10385618

p73
type: DnaRegionReference
xref: HUGO c gn141 TP73

Pubmed_12446714
type: PublicationXref
id: 12446714
db: pubmed

HUGO c gn101 MRPL27
type: RelationshipXref
id: MRPL27
db: HGNC

SERPINE1
type: DnaRegionReference
xref: HUGO c gn16 SERPINE1

HUGO c gn121 NDC80
type: RelationshipXref
id: NDC80
db: HGNC

c0 c re86
type: Catalysis
controlled: c re86
control type: ACTIVATION
controller: CDK2_CyclinA
comment: CDTYPE:CATALYSIS

Pubmed_9679058
type: PublicationXref
id: 9679058
db: pubmed

PCAF
type: ProteinReference
xref: HUGO e pr16 KAT2B
xref: Pubmed_15121871

DNMT1
type: DnaRegionReference
xref: HUGO c gn43 DNMT1

Pubmed_12368233
type: PublicationXref
id: 12368233
db: pubmed

Pubmed_15175242
type: PublicationXref
id: 15175242
db: pubmed

PFKFB
type: DnaRegionReference
xref: HUGO c gn71 PFKFB2
xref: HUGO c gn71 PFKFB1
xref: HUGO c gn71 PFKFB4
xref: HUGO c gn71 PFKFB3

HUGO e gn144 AXIN2
type: RelationshipXref
id: AXIN2
db: HGNC

c0 c re92
type: Catalysis
controlled: c re92
control type: ACTIVATION
controller: CDK6_CyclinD__p27KIP1
comment: CDTYPE:CATALYSIS

Pubmed_15510213
type: PublicationXref
id: 15510213
db: pubmed

FHIT
type: DnaRegionReference
xref: HUGO c gn22 FHIT

p68
type: DnaRegionReference
xref: HUGO c gn69 POLD3

c0 c re98
type: Catalysis
controlled: c re98
control type: ACTIVATION
controller: HDAC1
comment: CDTYPE:CATALYSIS

HUGO e pr115 CDKN1A
type: RelationshipXref
id: CDKN1A
db: HGNC

c1 c re179
type: Catalysis
controlled: c re179
control type: ACTIVATION
controller: p21CIP1
comment: CDTYPE:CATALYSIS

Pubmed_9889122
type: PublicationXref
id: 9889122
db: pubmed

c1 c re178
type: Catalysis
controlled: c re178
control type: ACTIVATION
controller: p21CIP1
comment: CDTYPE:CATALYSIS

HUGO c p32 PCGF2
type: RelationshipXref
id: PCGF2
db: HGNC

PHC1
type: ProteinReference
xref: HUGO c p33 PHC1

RAD54L
type: DnaRegionReference
xref: HUGO c gn92 RAD54L

Pubmed_10964686
type: PublicationXref
id: 10964686
db: pubmed

HUGO e pr167 BMI1
type: RelationshipXref
id: BMI1
db: HGNC

c0 c re135
type: Catalysis
controlled: c re135
control type: ACTIVATION
controller: CHEK1
comment: CDTYPE:CATALYSIS

c0 c re132
type: Catalysis
controlled: c re132
control type: ACTIVATION
controller: CHEK2
comment: CDTYPE:CATALYSIS

GAB2
type: DnaRegionReference
xref: HUGO c gn90 GAB2

c0 c re130
type: Catalysis
controlled: c re130
control type: ACTIVATION
controller: ATM_NBS1
comment: CDTYPE:CATALYSIS

HUGO a gn4 MCL1
type: RelationshipXref
id: MCL1
db: HGNC

UBB
type: DnaRegionReference
xref: HUGO c gn179 UBB

HUGO a gn30 APAF1
type: RelationshipXref
id: APAF1
db: HGNC

SSR4
type: DnaRegionReference
xref: HUGO c gn169 SSR4

Pubmed_8760872
type: PublicationXref
id: 8760872
db: pubmed

E2F5
type: ProteinReference
xref: HUGO c p9 E2F5
xref: Pubmed_15838516
xref: Pubmed_15126619

c0 c re147
type: Catalysis
controlled: c re147
control type: ACTIVATION
controller: CDK7_CyclinH__MNAT1
comment: CDTYPE:CATALYSIS

c0 c re35
type: Catalysis
controlled: c re35
control type: ACTIVATION
controller: PPP1C__PPP1R
comment: CDTYPE:CATALYSIS

Pubmed_11533237
type: PublicationXref
id: 11533237
db: pubmed

c0 c re141
type: Catalysis
controlled: c re141
control type: ACTIVATION
controller: ATM
comment: CDTYPE:CATALYSIS

c0 c re142
type: Catalysis
controlled: c re142
control type: ACTIVATION
controller: ATR
comment: CDTYPE:CATALYSIS

HUGO c pr140 PPP1R1C
type: RelationshipXref
id: PPP1R1C
db: HGNC

HUGO c pr140 PPP1R1A
type: RelationshipXref
id: PPP1R1A
db: HGNC

Pubmed_9315635
type: PublicationXref
id: 9315635
db: pubmed

c1 c re195
type: Catalysis
controlled: c re195
control type: ACTIVATION
controller: CDK1_CyclinB
comment: CDTYPE:CATALYSIS

Pubmed_15574595
type: PublicationXref
id: 15574595
db: pubmed

SIN3B
type: ProteinReference
xref: HUGO c p15 SIN3B

Caspase7
type: DnaRegionReference
xref: HUGO a gn92 CASP7

Pubmed_15272308
type: PublicationXref
id: 15272308
db: pubmed

module_INK4
type: Pathway
pathway component: c re165
pathway component: c re166
pathway component: c re167
pathway component: c re168
pathway component: c re247
pathway component: c0 c re247
pathway component: c0 c re165
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

CyclinH
type: ProteinReference
xref: HUGO d pr71 CCNH

HUGO c p82 CDC16
type: RelationshipXref
id: CDC16
db: HGNC

HUGO c p82 CDC26
type: RelationshipXref
id: CDC26
db: HGNC

module_APC
type: Pathway
pathway component: c0 c re258
pathway component: c0 c re257
pathway component: c0 c re255
pathway component: c0 c re195
pathway component: c re261
pathway component: c re260
pathway component: c re258
pathway component: c re257
pathway component: c re254
pathway component: c re255
pathway component: c re253
pathway component: c1 c re258
pathway component: c0 c re260
pathway component: c0 c re261
pathway component: c1 c re195
pathway component: c re195
pathway component: c1 c re257
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

HUGO c p82 CDC23
type: RelationshipXref
id: CDC23
db: HGNC

p15INK4B
type: ProteinReference
xref: Pubmed_10773440
xref: Pubmed_10385618
xref: HUGO e pr109 CDKN2B

HUGO c p82 CDC27
type: RelationshipXref
id: CDC27
db: HGNC

HUGO c pr140 PPP1R3D
type: RelationshipXref
id: PPP1R3D
db: HGNC

c0 c re121
type: Catalysis
controlled: c re121
control type: ACTIVATION
controller: CDK3_CyclinC
comment: CDTYPE:CATALYSIS

HUGO c p19 TFDP2
type: RelationshipXref
id: TFDP2
db: HGNC

CYC1
type: DnaRegionReference
xref: HUGO c gn55 CYC1

HUGO c gn110 FBXO5
type: RelationshipXref
id: FBXO5
db: HGNC

HP1gamma
type: ProteinReference
xref: HUGO c p37 CBX3

Pubmed_16275992
type: PublicationXref
id: 16275992
db: pubmed

E2F5
type: Protein
entity reference: E2F5

ACR
type: DnaRegionReference
xref: HUGO c gn116 ACR

Pubmed_15558010
type: PublicationXref
id: 15558010
db: pubmed

Pubmed_12110166
type: PublicationXref
id: 12110166
db: pubmed

Pubmed_8259215
type: PublicationXref
id: 8259215
db: pubmed

HUGO c gn90 GAB2
type: RelationshipXref
id: GAB2
db: HGNC

HUGO a pr653 RB1
type: RelationshipXref
id: RB1
db: HGNC

Pubmed_11883935
type: PublicationXref
id: 11883935
db: pubmed

MXD3
type: DnaRegionReference
xref: HUGO c gn30 MXD3

FZR1_at_Nucleus
type: Protein
entity reference: FZR1

Pubmed_12389032
type: PublicationXref
id: 12389032
db: pubmed

Pubmed_11897663
type: PublicationXref
id: 11897663
db: pubmed

Pubmed_12524548
type: PublicationXref
id: 12524548
db: pubmed

HOXA3
type: DnaRegionReference
xref: HUGO c gn119 HOXA3

HUGO a pr590 HSP90AA1
type: RelationshipXref
id: HSP90AA1
db: HGNC

HUGO c gn183 WWOX
type: RelationshipXref
id: WWOX
db: HGNC

Pubmed_8001816
type: PublicationXref
id: 8001816
db: pubmed

Pubmed_15177020
type: PublicationXref
id: 15177020
db: pubmed

Pubmed_11564866
type: PublicationXref
id: 11564866
db: pubmed

PPP1R
type: ProteinReference
xref: HUGO c pr140 PPP1R2
xref: HUGO c pr140 PPP1R3D
xref: HUGO c pr140 PPP1R1C
xref: HUGO c pr140 PPP1R1A

HUGO a pr446 CDKN2A
type: RelationshipXref
id: CDKN2A
db: HGNC

HUGO c p78 CDC37
type: RelationshipXref
id: CDC37
db: HGNC

CDK4
type: ProteinReference
xref: Pubmed_10498883
xref: HUGO e pr111 CDK4
xref: Pubmed_10385618

DHFR
type: DnaRegionReference
xref: HUGO c gn61 DHFR

HUGO d pr279 PKMYT1
type: RelationshipXref
id: PKMYT1
db: HGNC

HUGO a gn90 CASP8
type: RelationshipXref
id: CASP8
db: HGNC

BBC3
type: DnaRegionReference
xref: HUGO a gn6 BBC3

HUGO c gn3 PPARG
type: RelationshipXref
id: PPARG
db: HGNC

HUGO c p10 E2F6
type: RelationshipXref
id: E2F6
db: HGNC

THEM2
type: DnaRegionReference
xref: HUGO c gn172 ACOT13

HUGO c gn48 RPA2
type: RelationshipXref
id: RPA2
db: HGNC

CDCA7
type: DnaRegionReference
xref: HUGO c gn191 CDCA7

SUZ12
type: DnaRegionReference
xref: HUGO c gn170 SUZ12

NBS1
type: ProteinReference
xref: HUGO a pr920 NBN

Pubmed_14576826
type: PublicationXref
id: 14576826
db: pubmed

HUGO c gn43 DNMT1
type: RelationshipXref
id: DNMT1
db: HGNC

Pubmed_15936277
type: PublicationXref
id: 15936277
db: pubmed

E2F3_alone
type: ProteinReference
xref: HUGO c pr137 E2F3

TRIM55
type: DnaRegionReference
xref: HUGO c gn181 TRIM55

CHEK1
type: DnaRegionReference
xref: HUGO d gn84 CHEK1

Pubmed_15231644
type: PublicationXref
id: 15231644
db: pubmed

c1 c re132
type: Catalysis
controlled: c re132
control type: ACTIVATION
controller: ATM_NBS1
comment: CDTYPE:CATALYSIS

HUGO c pr137 E2F3
type: RelationshipXref
id: E2F3
db: HGNC

HUGO d gn71 CCNE1
type: RelationshipXref
id: CCNE1
db: HGNC

HUGO d gn71 CCNE2
type: RelationshipXref
id: CCNE2
db: HGNC

c1 c re135
type: Catalysis
controlled: c re135
control type: ACTIVATION
controller: CHEK2
comment: CDTYPE:CATALYSIS

HUGO c gn184 ZNF83
type: RelationshipXref
id: ZNF83
db: HGNC

HUGO c gn76 MCM10
type: RelationshipXref
id: MCM10
db: HGNC

Pubmed_10766737
type: PublicationXref
id: 10766737
db: pubmed

HUGO a gn92 CASP7
type: RelationshipXref
id: CASP7
db: HGNC

HUGO c gn35 ACTG1
type: RelationshipXref
id: ACTG1
db: HGNC

ATM
type: ProteinReference
xref: HUGO e p47 ATM

RBL1
type: DnaRegionReference
xref: HUGO c gn194 RBL1

HUGO c p52 SUV39H1
type: RelationshipXref
id: SUV39H1
db: HGNC

EIF2AK2
type: DnaRegionReference
xref: HUGO c gn44 EIF2AK2

HUGO a gn9 BIRC5
type: RelationshipXref
id: BIRC5
db: HGNC

CyclinB2
type: DnaRegionReference
xref: HUGO c gn70 CCNB2

p14ARF__at_Nucleolus
type: Protein
entity reference: p14ARF

p14ARF__at_Nucleus
type: Protein
entity reference: p14ARF

Pubmed_12665581
type: PublicationXref
id: 12665581
db: pubmed

CyclinD__Thr286_pho_at_Cytoplasm
type: Protein
entity reference: CyclinD
feature: c s1540 c rs1 phosphorylated

Pubmed_15014447
type: PublicationXref
id: 15014447
db: pubmed

CDK6_CyclinD
type: Complex
component: CyclinD__Thr286_pho_at_Cytoplasm
component: CDK6_at_Cytoplasm

FZR1
type: ProteinReference
xref: HUGO a pr791 FZR1

CDK6_at_Cytoplasm
type: Protein
entity reference: CDK6

p14ARF__at_Nucleolus
type: Protein
entity reference: p14ARF

p14ARF
type: Protein
entity reference: p14ARF

p14ARF__at_Nucleus
type: Protein
entity reference: p14ARF

EHMT1
type: ProteinReference
xref: HUGO c p42 EHMT1

Pubmed_12814430
type: PublicationXref
id: 12814430
db: pubmed

HUGO d pr23 CDC20
type: RelationshipXref
id: CDC20
db: HGNC

p14ARF__at_Nucleolus
type: Protein
entity reference: p14ARF

HUGO c gn130 TK1
type: RelationshipXref
id: TK1
db: HGNC

HUGO c p23 CCNB3
type: RelationshipXref
id: CCNB3
db: HGNC

HUGO c p23 CCNB2
type: RelationshipXref
id: CCNB2
db: HGNC

HUGO c p23 CCNB1
type: RelationshipXref
id: CCNB1
db: HGNC

Pubmed_16431910
type: PublicationXref
id: 16431910
db: pubmed

MCM7
type: DnaRegionReference
xref: HUGO a gn28 MCM7

Pubmed_11313986
type: PublicationXref
id: 11313986
db: pubmed

LGALS1
type: DnaRegionReference
xref: HUGO c gn26 LGALS1

Pubmed_10773440
type: PublicationXref
id: 10773440
db: pubmed

HUGO c gn148 RRM2
type: RelationshipXref
id: RRM2
db: HGNC

Pubmed_14633988
type: PublicationXref
id: 14633988
db: pubmed

Pubmed_16512785
type: PublicationXref
id: 16512785
db: pubmed

E2F7
type: DnaRegionReference
xref: HUGO c gn126 E2F7

BAT8__DP1__E2F6_EHMT1_MAX_MGA
type: Complex
component: E2F6_at_Nucleus
component: EHMT1_at_Nucleus
component: BAT8__at_Nucleus
component: MGA_at_Nucleus
component: DP1__at_Nucleus
component: MAX_at_Nucleus

PPP1R__at_Nucleus
type: Protein
entity reference: PPP1R

CDK2_CyclinE__p130
type: Complex
component: CyclinE__at_Nucleus
component: p130__pho_at_Nucleus
component: CDK2_Thr160_pho_at_Nucleus

FOXO1
type: DnaRegionReference
xref: HUGO c gn153 FOXO1

CDK2_CyclinE__p107
type: Complex
component: CDK2_Thr160_pho_at_Nucleus
component: CyclinE__at_Nucleus
component: p107__at_Nucleus

BAF250__DP1__E2F1_RB1
type: Complex
component: E2F1_at_Nucleus
component: RB1_pho_pho_at_Nucleus
component: BAF250__at_Nucleus
component: DP1__at_Nucleus

SPAG7
type: DnaRegionReference
xref: HUGO c gn167 SPAG7

HSP90
type: Complex

CDC37
type: Protein
entity reference: CDC37

HSP90
type: Protein
entity reference: HSP90

Pubmed_12697828
type: PublicationXref
id: 12697828
db: pubmed

HUGO a gn6 BBC3
type: RelationshipXref
id: BBC3
db: HGNC

WEE1
type: Protein
entity reference: WEE1
feature: c s1117 c rs1 phosphorylated

E2F6
type: Protein
entity reference: E2F6

Pubmed_12773400
type: PublicationXref
id: 12773400
db: pubmed

HUGO c p31 RING1
type: RelationshipXref
id: RING1
db: HGNC

HUGO e gn142 EZH2
type: RelationshipXref
id: EZH2
db: HGNC

p21CIP1__at_Nucleus
type: Protein
entity reference: p21CIP1

E2F1_p14ARF
type: Complex
component: p14ARF__at_Nucleolus
component: E2F1_at_Nucleolus

E2F1_at_Nucleolus
type: Protein
entity reference: E2F1

p21CIP1__at_Nucleus
type: Protein
entity reference: p21CIP1

CDK2_Thr160_pho_at_Nucleus
type: Protein
entity reference: CDK2
feature: c s1511 c rs1 phosphorylated

Pubmed_16213134
type: PublicationXref
id: 16213134
db: pubmed

EED_at_Nucleus
type: Protein
entity reference: EED

p21CIP1
type: Protein
entity reference: p21CIP1
feature: c s1100 c rs1 phosphorylated

DP1__at_Nucleus
type: Protein
entity reference: DP1

EZH2_at_Nucleus
type: Protein
entity reference: EZH2

HUGO d pr15 CCNE1
type: RelationshipXref
id: CCNE1
db: HGNC

HUGO d pr15 CCNE2
type: RelationshipXref
id: CCNE2
db: HGNC

Pubmed_14684737
type: PublicationXref
id: 14684737
db: pubmed

Pubmed_15577895
type: PublicationXref
id: 15577895
db: pubmed

MAX
type: ProteinReference
xref: HUGO a pr662 MAX

DP1__at_Nucleolus
type: Protein
entity reference: DP1

CDK1_Thr161_pho_at_Nucleus
type: Protein
entity reference: CDK1
feature: c s1522 c rs1 phosphorylated

CyclinB
type: Protein
entity reference: CyclinB

DP2__at_Nucleus
type: Protein
entity reference: DP2

p21CIP1
type: Protein
entity reference: p21CIP1
feature: c s1524 c rs1 phosphorylated

DP1__p14ARF
type: Complex
component: DP1__at_Nucleolus
component: p14ARF__at_Nucleolus

MDM2_at_Nucleolus
type: Protein
entity reference: MDM2

MDM2_p14ARF
type: Complex
component: p14ARF__at_Nucleolus
component: MDM2_at_Nucleolus

HUGO c gn64 RBBP8
type: RelationshipXref
id: RBBP8
db: HGNC

HUGO c gn158 NRP1
type: RelationshipXref
id: NRP1
db: HGNC

DP1__at_Cytoplasm
type: Protein
entity reference: DP1

CDK6_at_Cytoplasm
type: Protein
entity reference: CDK6

p16INK4A__at_Cytoplasm
type: Protein
entity reference: p16INK4A

APC_C__FZR1
type: Complex
component: APC_C__at_Nucleus
component: FZR1_at_Nucleus

module_RB
type: Pathway
pathway component: c2 c re298
pathway component: c re291
pathway component: c1 c re298
pathway component: c re323
pathway component: c0 c re298
pathway component: c re121
pathway component: c re112
pathway component: c re111
pathway component: c re122
pathway component: c0 c re35
pathway component: c re113
pathway component: c0 c re121
pathway component: c re35
pathway component: c re97
pathway component: c3 c re298
pathway component: c0 c re323
pathway component: c re298
comment: Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr
organism: Homo sapiens

PPP1C__PPP1R
type: Complex
component: PPP1C__at_Nucleus
component: PPP1R__at_Nucleus

CDC25C
type: Protein
entity reference: CDC25C
feature: c s1528 c rs1 phosphorylated
feature: c s1528 c rs2 phosphorylated

CDC25C
type: Protein
entity reference: CDC25C

Pubmed_11313932
type: PublicationXref
id: 11313932
db: pubmed

E2F6_at_Cytoplasm
type: Protein
entity reference: E2F6

PKMYT1
type: Protein
entity reference: PKMYT1

MCM10
type: DnaRegionReference
xref: HUGO c gn76 MCM10

p53
type: Protein
entity reference: p53

HUGO a gn14 BCL2L11
type: RelationshipXref
id: BCL2L11
db: HGNC

MDM2_at_Cytoplasm
type: Protein
entity reference: MDM2

Pubmed_14597855
type: PublicationXref
id: 14597855
db: pubmed

p53__at_Cytoplasm
type: Protein
entity reference: p53

MDM2
type: Protein
entity reference: MDM2

MDM2_p53
type: Complex
component: MDM2_at_Cytoplasm
component: p53__at_Cytoplasm

EHMT1_at_Nucleus
type: Protein
entity reference: EHMT1